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hey@getstride.com
Stride Health Group
Stride Health Group Ltd
Company No 05158025
Lamas Road
Badersfield
Norwich
England
NR10 5FB
UK
BLACK FRIDAY IS HERE - UP TO 30% OFF
Optimal DNA & Methylation Test
Your at-home DNA methylation test to optimise longevity
Learn how DNA shapes your internal biology to find optimal health across methylation, nutrition, fitness, skin, sleep & stress
Excellent Score 4.8 out of 5
- Explore 46 DNA insights across methylation pathways, nutrition, and lifestyle
- Understand how your genes influence a range of wellness traits including recovery, detoxification and ageing
- Use your results to optimise diet, supplements and daily routines for lifelong balance
- Includes 1:1 consultation to discuss your results
- Simple at home cheek swab test, with results in 10 days
Pay in 4 interest-free instalments of £XXX with Klarna
Secure, private platform
30-day money-back guarantee
As featured in
50%+
of adults have genetic variations disrupting methylation, the process that controls mood, detox, and hormone balance.
Constant fatigue
Low mood / stress
Hormonal imbalance
Slow recovery
Methylation Explained
Take your health to the next level, with our advanced DNA screening test
Your DNA holds the blueprint of how your body truly works. Stride's Optimal DNA & Methylation reveals that blueprint in remarkable detail - combining advanced methylation analysis with extended genetic insights into nutrition, sleep, stress, fitness, and skin health. It’s the most complete at-home methylation test available, designed to help you understand, optimise, and master your biology.
Methylation is one of the body’s most important regulatory systems - controlling gene expression, detoxification, energy production, and cellular repair. When methylation is efficient, your body performs at its best. When it isn’t, fatigue, inflammation, and poor recovery can take hold. Your Optimal DNA & Methylation results show exactly how well these cycles are working, highlighting key pathways such as the Folate, Methionine, BH4, and Transsulphuration cycles, plus how your genes interact across more than 9,000 genetic markers.
But this test doesn’t stop at methylation. With over 45 individual DNA reports, you’ll also uncover how your genetics influence metabolism, nutrient needs, collagen formation, recovery efficiency, sleep rhythm, and resilience to stress - the core systems that determine your energy, longevity, and daily performance.
Stride goes far beyond standard DNA kits. We operate our own UK-based laboratory for faster turnaround (typically within ten business days) and deliver your results through an interactive digital health platform - not a static PDF. Each test includes 1:1 expert support from our dieticians and human-health practitioners, helping you turn genetic data into clear, actionable steps. It’s precision health, made personal - the smarter way to optimise your methylation and perform at your genetic best.
Reports
There’s more to methylation testing with Stride
Your results live in MyStride, a fast, clear portal with expert guidance. No PDFs. Actionable next steps.
Methylation Profile Reports
Understand how your folate, methionine, BH4, and transsulphuration cycles are wired.
Helps with: DNA repair, detox, neurotransmitters, energy.
Includes: 5 reports
Nutrition Reports
See how your genes shape vitamin/mineral needs and carb/fat handling.
Helps with: intake, intolerances, better absorption.
Includes: 24 reports
Fitness Reports
Train the way your body responds best. Avoid wasted effort and plateaus.
Helps with: intensity, recovery, injury risk, programming.
Includes: 4 reports
Sleep & Stress Reports
Work with your natural rhythm and resilience. Wake restored; stay calm daily.
Helps with: chronotype, sleep quality, coping under stress.
Includes: 5 reports
Skin Reports
Target what your skin actually needs. Personalised care for visible results.
Helps with: DNA repair, detox, neurotransmitters, energy.
Includes: 5 reports
US VS THEM
Why smart optimisers choose Stride
Get faster results, deeper insights, and real guidance, not just data. Here’s how Stride stacks up.
| Stride Optimal DNA & Methylation | Ultimate Human | 10x Health System | |
|---|---|---|---|
| Genes analysed | 110 | 13 | 5 |
| Results time | 10 days | 5 weeks | 4 weeks |
| 1:1 Expert consultation |  |
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| Personalised plan | |
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| Money-back guarantee | |
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| Price | USD 335.30 | £499 | $599 |
Join tens of thousands already taking control of their health.
Real reviews from Stride users.
Full stack precision health
Stride is a holistic personalised health ecosystem. By joining us with a StrideDNA test you’ll unlock access to everything Stride offers, from further diagnostic testing to cutting-edge supplementation.
Phase 1: Assessment
Choose your report insight level and order your Optimal DNA & Methylation test kit.
🧬 StrideDNA At-Home Test
We’ll ship you our easy-to-use home DNA testing kit, for a world of insights with just a simple cheek swab.
Phase 2: Discovery
Return your StrideDNA kit using our prepaid return mailer and we’ll analyse your sample at our advanced in-house laboratory.
💉 Precision laboratory analysis
We’ll extract your DNA and analyse your sample for over 9000 genetic locations, all within ten working days
📊 Genetic reports
You'll get over 50 detailed genetic reports including methylation profile.
Phase 3: Action
Once you’ve got your StrideDNA results, you’ll unlock a world of personalised health insights with clear support for next steps.
💧 Supplements
With your results, you’ll unlock eligibility for one of our tailored supplements, either StrideDaily or MS-01.
🩺 1:1 Expert Consultation
Our team of holistic functional health practitioners are available for free consultations to help reach your goals.
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Daily support stack with active-form vitamin B6, B9 & B12 to support methylation.
Learn MoreFor the curious.
What is the Optimal DNA & Methylation Test?
Our most comprehensive option combining methylation, nutrigenetics, fitness, sleep & stress, and skin genetics to give a complete view of your health blueprint.
Why is methylation important for health, and how do genetic variants affect it?
Methylation is a core biochemical process that supports gene expression, detoxification, energy production, immune function, neurotransmitter balance, and lipid metabolism.
Genetic variants in methylation-related genes (e.g., MTHFR, MTR, MTRR, COMT, BHMT, CBS) can influence how efficiently your body converts and uses nutrients such as folate and B12, which may affect energy, mood, cardiovascular and neurological health.
Understanding your variants helps tailor nutrition and supplementation (e.g., folate form and dose, B-vitamin support), alongside lifestyle changes to optimise methylation.
What's included with the Optimal DNA & Methylation Test?
Your package includes:
- At-home DNA test kit + prepaid UK lab return
- 5 Methylation Reports
- 24 Nutrigenetic Reports
- 4 Genetic Fitness Reports: Power/Endurance, Aerobic Training Response, Recovery Efficiency, Injury Predisposition
- 5 Genetic Mental Cognition (Sleep + Stress) Reports: Chronotype, Sleep Quality, Caffeine & Sleep Response, Stress Tolerance, Warrior/Strategist
- 7 Genetic Skin Reports: Skin Ageing, Oxidative Stress Impact, Carb/Glycation Sensitivity, Pigmentation, Nickel Sensitivity, Detoxification, Inflammation
- 1:1 Health Expert Support (including dietician)
- Stride digital health platform
What methylation pathways does it analyse?
The Optimal test includes the full methylation foundation: Folate Cycle, Methionine Cycle, Transsulphuration Pathway, BH4 Cycle, and Urea Cycle.
What methylation genes are included?
It includes the same core methylation gene panel used in Core/Advanced—e.g., MTHFR (C677T, A1298C), MTR, MTRR, COMT, BHMT, CBS, MAOA, MAOB, DHFR, FUT2, NOS3, PEMT, SOD2, TCN2, and VDR—within a 9,000+ locus analysis.
Why is the AHCY gene not included in Stride's Methylation Report?
To maximise relevance and actionability, we exclude variants deemed benign or extremely rare with serious pathology.
AHCY SNPs rs41301825 and rs13043752 are benign and uncommon; rs121918608 is a rare pathogenic mutation, so it isn't appropriate for routine reporting.
How does the Optimal test differ from the Advanced test?
Optimal includes everything in Advanced and adds fitness performance/recovery, sleep & stress traits, and skin ageing/inflammation insights for a complete, longevity-focused view.
How can this test benefit my health?
You'll get precise guidance for nutrition and supplements plus insights to optimise training, recovery, sleep quality, stress resilience, and skin health.
What kind of support do I receive with my StrideDNA Test?
All plans include 1:1 consultations with qualified dieticians and health practitioners who help interpret your reports and turn them into an actionable plan.
How long does it take to receive my results?
Results are typically delivered within 10 business days after your sample reaches our UK laboratory.
Where is the methylation test available?
Global shipping from the UK across the UK, Europe, North America, Asia-Pacific, Oceania, South America, and Africa. Delivery times and customs charges vary. For unlisted countries, contact hey@getstride.com.
Can I take this test if I’m under 18?
StrideDNA tests are designed for adults (18+).
If you are under 18, testing should only be arranged by a parent or legal guardian, and ideally interpreted with a qualified healthcare professional. Regulatory rules and availability for minors can vary by country.
If you’re unsure, email hey@getstride.com and we’ll advise before you order.