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Stride Health Group
Stride Health Group Ltd
Company No 05158025
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Norwich
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NR10 5FB
UK
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Core Methylation Test
Your at-home DNA methylation test for better health
Analyse 5 key methylation pathways and turn insights into action
Excellent Score 4.8 out of 5
- Explore five key methylation cycles (folate, methionine, transsulphuration, BH4, urea)
- See how efficiently you detoxify, repair DNA, and convert nutrients into energy
- Choose diet types and supplements guided by genes such as MTHFR, COMT, and others
Pay in 4 interest-free instalments of £XXX with Klarna
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30-day money-back guarantee
As featured in
50%+
of adults have genetic variations disrupting methylation, the process that controls mood, detox, and hormone balance.
Constant fatigue
Low mood / stress
Hormonal imbalance
Slow recovery
Methylation Explained
Build your foundation with essential DNA methylation insights
Have you ever wondered why the same health advice doesn’t work for everyone? The answer may lie in your methylation profile — a key biological process that helps control how your genes function. When these pathways aren’t working optimally, your body may struggle to perform at its best.
Methylation is similar to transforming raw materials into usable forms, playing a role in nearly every biochemical reaction within our cells, happening billions times per second.
Methylation is crucial for numerous body processes, including gene expression, energy production, fat metabolism, immune responses, detoxification and neurotransmitter regulation. Factors like DNA, diet, toxin exposure, and stress influence methylation.
Genetic mutations and deficiencies in key dietary cofactors (e.g., the MTHFR gene) can impair methylation and affect the body's ability to convert nutrients effectively. This can cause various chronic conditions, such as impaired immunity, fatigue, cardiovascular disease, neurological disorders, cancers, and mood disorders.
Reports
There’s more to methylation testing with Stride
Your results live in MyStride, a fast, clear portal with expert guidance. No PDFs. Actionable next steps.
Methylation Profile Reports
Understand how your folate, methionine, BH4, and transsulphuration cycles are wired.
Helps with: DNA repair, detox, neurotransmitters, energy.
Includes: 5 reports
Nutrition Reports
See how your genes shape vitamin/mineral needs and carb/fat handling.
Helps with: intake, intolerances, better absorption.
Includes: 24 reports
Fitness Reports
Train the way your body responds best. Avoid wasted effort and plateaus.
Helps with: intensity, recovery, injury risk, programming.
Includes: 4 reports
Sleep & Stress Reports
Work with your natural rhythm and resilience. Wake restored; stay calm daily.
Helps with: chronotype, sleep quality, coping under stress.
Includes: 5 reports
Skin Reports
Target what your skin actually needs. Personalised care for visible results.
Helps with: DNA repair, detox, neurotransmitters, energy.
Includes: 5 reports
US VS THEM
Why smart optimisers choose Stride
Get faster results, deeper insights, and real guidance, not just data. Here’s how Stride stacks up.
| Stride Core Methylation | Ultimate Human | 10x Health System | |
|---|---|---|---|
| Genes analysed | 19 | 13 | 5 |
| Results time | 10 days | 5 weeks | 4 weeks |
| 1:1 Expert consultation |  |
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| Personalised plan | |
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| Money-back guarantee | |
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| Price | USD 260.10 | £499 | $599 |
Join tens of thousands already taking control of their health.
Real reviews from Stride users.
Full stack precision health
Stride is a holistic personalised health ecosystem. By joining us with a StrideDNA test you’ll unlock access to everything Stride offers, from further diagnostic testing to cutting-edge supplementation.
Phase 1: Assessment
Choose your report insight level and order your Core Methylation test kit.
🧬 StrideDNA At-Home Test
We’ll ship you our easy-to-use home DNA testing kit, for a world of insights with just a simple cheek swab.
Phase 2: Discovery
Return your StrideDNA kit using our prepaid return mailer and we’ll analyse your sample at our advanced in-house laboratory.
💉 Precision laboratory analysis
We’ll extract your DNA and analyse your sample for over 9000 genetic locations, all within ten working days
📊 Genetic reports
You'll get your 5 methylation pathway reports with clear, prioritised actions.
Phase 3: Action
Once you’ve got your StrideDNA results, you’ll unlock a world of personalised health insights with clear support for next steps.
💧 Supplements
With your results, you’ll unlock eligibility for one of our tailored supplements, either StrideDaily or MS-01.
🩺 1:1 Expert Consultation
Our team of holistic functional health practitioners are available for free consultations to help reach your goals.
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Daily support stack with active-form vitamin B6, B9 & B12 to support methylation.
Learn MoreFor the curious.
What is the Core Methylation Test?
The Stride Core Methylation Test is an at-home DNA test that analyses key methylation pathways and genetic markers affecting nutrient processing, detoxification, energy, and mood. It provides clear, actionable insights to help you personalise nutrition and supplements.
Why is methylation important for health, and how do genetic variants affect it?
Methylation is a core biochemical process that supports gene expression, detoxification, energy production, immune function, neurotransmitter balance, and lipid metabolism.
Genetic variants in methylation-related genes (e.g., MTHFR, MTR, MTRR, COMT, BHMT, CBS) can influence how efficiently your body converts and uses nutrients such as folate and B12, which may affect energy, mood, cardiovascular and neurological health.
Understanding your variants helps tailor nutrition and supplementation (e.g., folate form and dose, B-vitamin support), alongside lifestyle changes to optimise methylation.
What's included with the Core Methylation Test?
Your kit includes:
- Easy-to-use at-home DNA test kit
- Free return mailer to our UK laboratory
- 5 Methylation Reports: Folate Cycle, Methionine Cycle, Transsulphuration Pathway, BH4 Cycle, Urea Cycle
- 1:1 Health Expert Support (including dietician)
- Access to the Stride digital health platform
What methylation pathways does it analyse?
The Core Methylation Test covers the Folate Cycle, Methionine Cycle, Transsulphuration Pathway, BH4 Cycle, and Urea Cycle to help you understand where methylation efficiency may be supported.
What methylation genes are included?
The report evaluates over 9,000 locations and key SNPs such as MTHFR (C677T, A1298C), MTR, MTRR, COMT, BHMT, CBS, MAOA, MAOB, DHFR, FUT2, NOS3, PEMT, SOD2, TCN2, and VDR.
Why is the AHCY gene not included in Stride's Methylation Report?
We include genes with strong human evidence and clear, modifiable actions.
AHCY SNPs rs41301825 and rs13043752 are regarded as benign and rare; rs121918608 is a very rare pathogenic mutation. Including benign or ultra-rare variants would not add meaningful, actionable insight for most users.
How does the Core Methylation Test differ from other DNA tests?
Stride analyses more genetic locations than most methylation-only tests and delivers results via an interactive platform with expert support, helping you translate data into practical nutrition and supplement strategies.
How can this test benefit my health?
It identifies potential inefficiencies in methylation that can affect energy, detoxification, immune function, neurotransmitters, and nutrient conversion (e.g., folate), guiding targeted diet and supplement choices.
What kind of support do I receive with my StrideDNA Test?
Every Stride test includes 1:1 consultations with qualified dieticians and health practitioners. Our experts interpret your results and help you build a personalised plan.
How long does it take to receive my results?
Your results are typically available within 10 business days after your sample arrives at our UK laboratory.
Where is the methylation test available?
Stride ships globally from our UK-based laboratory across the UK, Europe, North America, Asia-Pacific, Oceania, South America, and Africa. Shipping times and any customs fees vary by location. If your country is not listed, contact hey@getstride.com.
Can I take this test if I’m under 18?
StrideDNA tests are designed for adults (18+).
If you are under 18, testing should only be arranged by a parent or legal guardian, and ideally interpreted with a qualified healthcare professional. Regulatory rules and availability for minors can vary by country.
If you’re unsure, email hey@getstride.com and we’ll advise before you order.