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hey@getstride.com
Stride Health Group
Stride Health Group Ltd
Company No 05158025
Lamas Road
Badersfield
Norwich
England
NR10 5FB
UK
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Core Methylation Test
Your at-home DNA methylation test for better health
Analyse 5 key methylation pathways and turn insights into action
Excellent Score 4.8 out of 5
- Explore five key methylation cycles (folate, methionine, transsulphuration, BH4, urea)
- See how efficiently you detoxify, repair DNA, and convert nutrients into energy
- Choose diet types and supplements guided by genes such as MTHFR, COMT, and others
Pay in 4 interest-free instalments of £XXX with Klarna
Secure, private platform
30-day money-back guarantee
As featured in
50%+
of adults have genetic variations disrupting methylation, the process that controls mood, detox, and hormone balance.
Constant fatigue
Low mood / stress
Hormonal imbalance
Slow recovery
Science
Unlocking the power of methylation: How your biology speaks to you
Methylation regulates how your genes work, detox, energise, repair, and age. The Stride DNA & Methylation Test reveals how well your system performs and how to optimise it for lifelong balance.
1. What is methylation?
A molecular switchboard inside your cells
Methylation is the addition (or removal) of tiny chemical groups called methyl groups (–CH₃) to molecules, including in your DNA. This doesn’t change your genetic code, but it can change how the code is interpreted, turning genes “on” or “off” and helping regulate energy, detoxification, cell repair and more.
What exactly gets methylated?
Most commonly, DNA and RNA molecules are methylated, but other proteins, neurotransmitters and phospholipids are also methylated as part of normal body functions.
How does methylation affect gene expression?
In genetics, methylation can block the binding of transcription factors or recruit proteins that compact DNA, making genes less likely to be read and used.
Is methylation permanent?
No. Methylation can change over time, in different tissues, and in response to environment, nutrition and age.
2. Why methylation matters
Key biological pathways depend on it
When methylation runs smoothly, your body efficiently handles detoxification, cell repair, energy metabolism, and even the pace of ageing. When it falters, you may see fatigue, inflammation, slower recovery, and greater disease risk. Abnormal methylation patterns are seen in cancers, metabolic disorders and ageing.
How does methylation affect detoxification and repair?
Methylation is tightly linked to producing methyl donors, clearing toxins, repairing DNA, and maintaining healthy, functional cells.
What happens when methylation is inefficient?
Inefficient methylation may reduce the capacity to switch genes on appropriately, impair detoxification, slow cell repair, increase inflammation and can accelerate ageing and the onset of disease.
Can lifestyle or nutrition influence methylation?
Yes. Diet, vitamin intake (especially B-vitamins such as folate), and environmental exposures (like pollution and toxins) all influence methylation patterns.
3. How Stride helps you
From insight → action: turn your methylation profile into optimisation
With the Stride Optimal DNA & Methylation test, you get a deep view of your methylation profile and how key pathways and genes function. We translate that into clear, actionable support through our digital platform and expert guidance to optimise your nutrients, lifestyle and performance.
What does the test reveal about my methylation system?
It shows your genetic variants (at over 9,000 locations) tied to methylation function, plus how efficiently your key methylation cycles and related pathways are working.
What do I do with the results?
Through your reports and a complimentary 1:1 expert consultation, we provide interpretation and personalised recommendations – from nutrient guidance and supplement requirements to lifestyle tweaks – to support your methylation pathways and overall biology.
How is this different from a standard DNA test?
Most tests look at a few gene variants. Stride delves deep into methylation-related pathways, gives you actionable insights (not just static data), and pairs that with expert support via our platform.
Reports
There’s more to methylation testing with Stride
Your results live in MyStride, a fast, clear portal with expert guidance. No PDFs. Actionable next steps.
Methylation Profile Reports
Understand how your folate, methionine, BH4, and transsulphuration cycles are wired.
Helps with: DNA repair, detox, neurotransmitters, energy.
Includes: 5 reports
Nutrition Reports
See how your genes shape vitamin/mineral needs and carb/fat handling.
Helps with: intake, intolerances, better absorption.
Includes: 24 reports
Fitness Reports
Train the way your body responds best. Avoid wasted effort and plateaus.
Helps with: intensity, recovery, injury risk, programming.
Includes: 4 reports
Sleep & Stress Reports
Work with your natural rhythm and resilience. Wake restored; stay calm daily.
Helps with: chronotype, sleep quality, coping under stress.
Includes: 5 reports
Skin Reports
Target what your skin actually needs. Personalised care for visible results.
Helps with: DNA repair, detox, neurotransmitters, energy.
Includes: 5 reports
US VS THEM
Why smart optimisers choose Stride
Get faster results, deeper insights, and real guidance, not just data. Here’s how Stride stacks up.
| Stride Core Methylation | Ultimate Human | 10x Health System | |
|---|---|---|---|
| Genes analysed | 19 | 13 | 5 |
| Results time | 10 days | 5 weeks | 4 weeks |
| 1:1 Expert consultation |  |
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|
| Personalised plan | |
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| Money-back guarantee | |
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| Price | USD 289 | £499 | $599 |
Join tens of thousands already taking control of their health.
Real reviews from Stride users.
The Stride Standard
Deeper Analysis
Most methylation tests on the market look at only a handful of genetic variants. StrideDNA analyse more than 9,000 genetic locations with every sample for the most precision picture of your health.
Data Security
We use strong technical and organisational measures to keep your data safe. It is stored securely and encrypted, and only accessible by the minimum necessary members of our team.
Expert Support
Forget hard to understand lab reports on a static PDF, with no support. StrideDNA results are delivered in your own interactive, world-class portal and every test includes 1:1 support from our expert team of human health practitioners.
Faster turnaround
Unlike almost every other test provider, we own and operate our own in-house laboratory here in the UK. This means we can be higher quality, lower cost and deliver results faster than anyone else.
Full stack precision health
Stride is a holistic personalised health ecosystem. By joining us with a StrideDNA test you’ll unlock access to everything Stride offers, from further diagnostic testing to cutting-edge supplementation.
Phase 1: Assessment
Choose your report insight level and order your Core Methylation test kit.
🧬 StrideDNA At-Home Test
We’ll ship you our easy-to-use home DNA testing kit, for a world of insights with just a simple cheek swab.
Phase 2: Discovery
Return your StrideDNA kit using our prepaid return mailer and we’ll analyse your sample at our advanced in-house laboratory.
💉 Precision laboratory analysis
We’ll extract your DNA and analyse your sample for over 9000 genetic locations, all within ten working days
📊 Genetic reports
You'll get your 5 methylation pathway reports with clear, prioritised actions.
Phase 3: Action
Once you’ve got your StrideDNA results, you’ll unlock a world of personalised health insights with clear support for next steps.
💧 Supplements
With your results, you’ll unlock eligibility for one of our tailored supplements, either StrideDaily or MS-01.
🩺 1:1 Expert Consultation
Our team of holistic functional health practitioners are available for free consultations to help reach your goals.
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MS-01
Daily support stack with active-form vitamin B6, B9 & B12 to support methylation.
Learn MoreFor the curious.
What is the Core Methylation Test?
The Stride Core Methylation Test is an at-home DNA test that analyses key methylation pathways and genetic markers affecting nutrient processing, detoxification, energy, and mood. It provides clear, actionable insights to help you personalise nutrition and supplements.
Why is methylation important for health, and how do genetic variants affect it?
Methylation is a core biochemical process that supports gene expression, detoxification, energy production, immune function, neurotransmitter balance, and lipid metabolism.
Genetic variants in methylation-related genes (e.g., MTHFR, MTR, MTRR, COMT, BHMT, CBS) can influence how efficiently your body converts and uses nutrients such as folate and B12, which may affect energy, mood, cardiovascular and neurological health.
Understanding your variants helps tailor nutrition and supplementation (e.g., folate form and dose, B-vitamin support), alongside lifestyle changes to optimise methylation.
What's included with the Core Methylation Test?
Your kit includes:
- Easy-to-use at-home DNA test kit
- Free return mailer to our UK laboratory
- 5 Methylation Reports: Folate Cycle, Methionine Cycle, Transsulphuration Pathway, BH4 Cycle, Urea Cycle
- 1:1 Health Expert Support (including dietician)
- Access to the Stride digital health platform
What methylation pathways does it analyse?
The Core Methylation Test covers the Folate Cycle, Methionine Cycle, Transsulphuration Pathway, BH4 Cycle, and Urea Cycle to help you understand where methylation efficiency may be supported.
What methylation genes are included?
The report evaluates over 9,000 locations and key SNPs such as MTHFR (C677T, A1298C), MTR, MTRR, COMT, BHMT, CBS, MAOA, MAOB, DHFR, FUT2, NOS3, PEMT, SOD2, TCN2, and VDR.
Why is the AHCY gene not included in Stride's Methylation Report?
We include genes with strong human evidence and clear, modifiable actions.
AHCY SNPs rs41301825 and rs13043752 are regarded as benign and rare; rs121918608 is a very rare pathogenic mutation. Including benign or ultra-rare variants would not add meaningful, actionable insight for most users.
How does the Core Methylation Test differ from other DNA tests?
Stride analyses more genetic locations than most methylation-only tests and delivers results via an interactive platform with expert support, helping you translate data into practical nutrition and supplement strategies.
How can this test benefit my health?
It identifies potential inefficiencies in methylation that can affect energy, detoxification, immune function, neurotransmitters, and nutrient conversion (e.g., folate), guiding targeted diet and supplement choices.
What kind of support do I receive with my StrideDNA Test?
Every Stride test includes 1:1 consultations with qualified dieticians and health practitioners. Our experts interpret your results and help you build a personalised plan.
How long does it take to receive my results?
Your results are typically available within 10 business days after your sample arrives at our UK laboratory.
Where is the methylation test available?
Stride ships globally from our UK-based laboratory across the UK, Europe, North America, Asia-Pacific, Oceania, South America, and Africa. Shipping times and any customs fees vary by location. If your country is not listed, contact hey@getstride.com.
Can I take this test if I’m under 18?
StrideDNA tests are designed for adults (18+).
If you are under 18, testing should only be arranged by a parent or legal guardian, and ideally interpreted with a qualified healthcare professional. Regulatory rules and availability for minors can vary by country.
If you’re unsure, email hey@getstride.com and we’ll advise before you order.