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Stride Health Group
Stride Health Group Ltd
Company No 05158025
Lamas Road
Badersfield
Norwich
England
NR10 5FB
UK
Optimal DNA & Methylation Test
Your at-home DNA methylation test to optimise longevity
Learn how DNA shapes your internal biology to find optimal health across methylation, nutrition, fitness, skin, sleep & stress
Excellent Score 4.8 out of 5
- Explore 46 DNA insights across methylation pathways, nutrition, and lifestyle
- Understand how your genes influence a range of wellness traits including recovery, detoxification and ageing
- Use your results to optimise diet, supplements and daily routines for lifelong balance
- Includes 1:1 consultation to discuss your results
- Simple at home cheek swab test, with results in 10 days
Pay in 4 interest-free instalments of £XXX with Klarna
Secure, private platform
30-day money-back guarantee
As featured in
50%+
of adults have genetic variations disrupting methylation, the process that controls mood, detox, and hormone balance.
Constant fatigue
Low mood / stress
Hormonal imbalance
Slow recovery
Science
Unlocking the power of methylation: How your biology speaks to you
Methylation regulates how your genes work, detox, energise, repair, and age. The Stride DNA & Methylation Test reveals how well your system performs and how to optimise it for lifelong balance.
1. What is methylation?
A molecular switchboard inside your cells
Methylation is the addition (or removal) of tiny chemical groups called methyl groups (–CH₃) to molecules, including in your DNA. This doesn’t change your genetic code, but it can change how the code is interpreted, turning genes “on” or “off” and helping regulate energy, detoxification, cell repair and more.
What exactly gets methylated?
Most commonly, DNA and RNA molecules are methylated, but other proteins, neurotransmitters and phospholipids are also methylated as part of normal body functions.
How does methylation affect gene expression?
In genetics, methylation can block the binding of transcription factors or recruit proteins that compact DNA, making genes less likely to be read and used.
Is methylation permanent?
No. Methylation can change over time, in different tissues, and in response to environment, nutrition and age.
2. Why methylation matters
Key biological pathways depend on it
When methylation runs smoothly, your body efficiently handles detoxification, cell repair, energy metabolism, and even the pace of ageing. When it falters, you may see fatigue, inflammation, slower recovery, and greater disease risk. Abnormal methylation patterns are seen in cancers, metabolic disorders and ageing.
How does methylation affect detoxification and repair?
Methylation is tightly linked to producing methyl donors, clearing toxins, repairing DNA, and maintaining healthy, functional cells.
What happens when methylation is inefficient?
Inefficient methylation may reduce the capacity to switch genes on appropriately, impair detoxification, slow cell repair, increase inflammation and can accelerate ageing and the onset of disease.
Can lifestyle or nutrition influence methylation?
Yes. Diet, vitamin intake (especially B-vitamins such as folate), and environmental exposures (like pollution and toxins) all influence methylation patterns.
3. How Stride helps you
From insight → action: turn your methylation profile into optimisation
With the Stride Optimal DNA & Methylation test, you get a deep view of your methylation profile and how key pathways and genes function. We translate that into clear, actionable support through our digital platform and expert guidance to optimise your nutrients, lifestyle and performance.
What does the test reveal about my methylation system?
It shows your genetic variants (at over 9,000 locations) tied to methylation function, plus how efficiently your key methylation cycles and related pathways are working.
What do I do with the results?
Through your reports and a complimentary 1:1 expert consultation, we provide interpretation and personalised recommendations – from nutrient guidance and supplement requirements to lifestyle tweaks – to support your methylation pathways and overall biology.
How is this different from a standard DNA test?
Most tests look at a few gene variants. Stride delves deep into methylation-related pathways, gives you actionable insights (not just static data), and pairs that with expert support via our platform.
Reports
There’s more to methylation testing with Stride
Your results live in MyStride, a fast, clear portal with expert guidance. No PDFs. Actionable next steps.
Methylation Profile Reports
Understand how your folate, methionine, BH4, and transsulphuration cycles are wired.
Helps with: DNA repair, detox, neurotransmitters, energy.
Includes: 5 reports
Nutrition Reports
See how your genes shape vitamin/mineral needs and carb/fat handling.
Helps with: intake, intolerances, better absorption.
Includes: 24 reports
Fitness Reports
Train the way your body responds best. Avoid wasted effort and plateaus.
Helps with: intensity, recovery, injury risk, programming.
Includes: 4 reports
Sleep & Stress Reports
Work with your natural rhythm and resilience. Wake restored; stay calm daily.
Helps with: chronotype, sleep quality, coping under stress.
Includes: 5 reports
Skin Reports
Target what your skin actually needs. Personalised care for visible results.
Helps with: DNA repair, detox, neurotransmitters, energy.
Includes: 5 reports
US VS THEM
Why smart optimisers choose Stride
Get faster results, deeper insights, and real guidance, not just data. Here’s how Stride stacks up.
| Stride Optimal DNA & Methylation | Ultimate Human | 10x Health System | |
|---|---|---|---|
| Genes analysed | 110 | 13 | 5 |
| Results time | 10 days | 5 weeks | 4 weeks |
| 1:1 Expert consultation |  |
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| Personalised plan | |
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| Money-back guarantee | |
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| Price | USD 383.20 | £499 | $599 |
Join tens of thousands already taking control of their health.
Real reviews from Stride users.
The Stride Standard
Deeper Analysis
Most methylation tests on the market look at only a handful of genetic variants. StrideDNA analyse more than 9,000 genetic locations with every sample for the most precision picture of your health.
Data Security
We use strong technical and organisational measures to keep your data safe. It is stored securely and encrypted, and only accessible by the minimum necessary members of our team.
Expert Support
Forget hard to understand lab reports on a static PDF, with no support. StrideDNA results are delivered in your own interactive, world-class portal and every test includes 1:1 support from our expert team of human health practitioners.
Faster turnaround
Unlike almost every other test provider, we own and operate our own in-house laboratory here in the UK. This means we can be higher quality, lower cost and deliver results faster than anyone else.
Full stack precision health
Stride is a holistic personalised health ecosystem. By joining us with a StrideDNA test you’ll unlock access to everything Stride offers, from further diagnostic testing to cutting-edge supplementation.
Phase 1: Assessment
Choose your report insight level and order your Optimal DNA & Methylation test kit.
🧬 StrideDNA At-Home Test
We’ll ship you our easy-to-use home DNA testing kit, for a world of insights with just a simple cheek swab.
Phase 2: Discovery
Return your StrideDNA kit using our prepaid return mailer and we’ll analyse your sample at our advanced in-house laboratory.
💉 Precision laboratory analysis
We’ll extract your DNA and analyse your sample for over 9000 genetic locations, all within ten working days
📊 Genetic reports
You'll get over 50 detailed genetic reports including methylation profile.
Phase 3: Action
Once you’ve got your StrideDNA results, you’ll unlock a world of personalised health insights with clear support for next steps.
💧 Supplements
With your results, you’ll unlock eligibility for one of our tailored supplements, either StrideDaily or MS-01.
🩺 1:1 Expert Consultation
Our team of holistic functional health practitioners are available for free consultations to help reach your goals.
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Daily support stack with active-form vitamin B6, B9 & B12 to support methylation.
Learn MoreFor the curious.
What is the Optimal DNA & Methylation Test?
Our most comprehensive option combining methylation, nutrigenetics, fitness, sleep & stress, and skin genetics to give a complete view of your health blueprint.
Why is methylation important for health, and how do genetic variants affect it?
Methylation is a core biochemical process that supports gene expression, detoxification, energy production, immune function, neurotransmitter balance, and lipid metabolism.
Genetic variants in methylation-related genes (e.g., MTHFR, MTR, MTRR, COMT, BHMT, CBS) can influence how efficiently your body converts and uses nutrients such as folate and B12, which may affect energy, mood, cardiovascular and neurological health.
Understanding your variants helps tailor nutrition and supplementation (e.g., folate form and dose, B-vitamin support), alongside lifestyle changes to optimise methylation.
What's included with the Optimal DNA & Methylation Test?
Your package includes:
- At-home DNA test kit + prepaid UK lab return
- 5 Methylation Reports
- 24 Nutrigenetic Reports
- 4 Genetic Fitness Reports: Power/Endurance, Aerobic Training Response, Recovery Efficiency, Injury Predisposition
- 5 Genetic Mental Cognition (Sleep + Stress) Reports: Chronotype, Sleep Quality, Caffeine & Sleep Response, Stress Tolerance, Warrior/Strategist
- 7 Genetic Skin Reports: Skin Ageing, Oxidative Stress Impact, Carb/Glycation Sensitivity, Pigmentation, Nickel Sensitivity, Detoxification, Inflammation
- 1:1 Health Expert Support (including dietician)
- Stride digital health platform
What methylation pathways does it analyse?
The Optimal test includes the full methylation foundation: Folate Cycle, Methionine Cycle, Transsulphuration Pathway, BH4 Cycle, and Urea Cycle.
What methylation genes are included?
It includes the same core methylation gene panel used in Core/Advanced—e.g., MTHFR (C677T, A1298C), MTR, MTRR, COMT, BHMT, CBS, MAOA, MAOB, DHFR, FUT2, NOS3, PEMT, SOD2, TCN2, and VDR—within a 9,000+ locus analysis.
Why is the AHCY gene not included in Stride's Methylation Report?
To maximise relevance and actionability, we exclude variants deemed benign or extremely rare with serious pathology.
AHCY SNPs rs41301825 and rs13043752 are benign and uncommon; rs121918608 is a rare pathogenic mutation, so it isn't appropriate for routine reporting.
How does the Optimal test differ from the Advanced test?
Optimal includes everything in Advanced and adds fitness performance/recovery, sleep & stress traits, and skin ageing/inflammation insights for a complete, longevity-focused view.
How can this test benefit my health?
You'll get precise guidance for nutrition and supplements plus insights to optimise training, recovery, sleep quality, stress resilience, and skin health.
What kind of support do I receive with my StrideDNA Test?
All plans include 1:1 consultations with qualified dieticians and health practitioners who help interpret your reports and turn them into an actionable plan.
How long does it take to receive my results?
Results are typically delivered within 10 business days after your sample reaches our UK laboratory.
Where is the methylation test available?
Global shipping from the UK across the UK, Europe, North America, Asia-Pacific, Oceania, South America, and Africa. Delivery times and customs charges vary. For unlisted countries, contact hey@getstride.com.
Can I take this test if I’m under 18?
StrideDNA tests are designed for adults (18+).
If you are under 18, testing should only be arranged by a parent or legal guardian, and ideally interpreted with a qualified healthcare professional. Regulatory rules and availability for minors can vary by country.
If you’re unsure, email hey@getstride.com and we’ll advise before you order.