DNA tests

MTHFR & Methylation Test

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€122.85

Find out how your body uses folate and B vitamins, and what to do about it.

  • Your MTHFR result: C677T and A1298C, and how many copies you carry
  • 18 methylation genes, including both MTHFR variants, with a report for each cycle
  • Cheek swab at home, results in about 10 working days
  • A 1:1 video consultation with a Stride nutrition specialist
  • An AI-powered protocol from all 18 genes, with supplement recommendations included
A bottle of MS-01 daily methylation support stack

Free gift

Free MS-01 4-week supply with this order

4-week supply of our daily support stack with active-form vitamin B6, B9 & B12 to support methylation — free with every health test or bundle, for a limited time.

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  • Free UK delivery. Kits usually arrive in 1 to 2 working days
  • Book your consultation in MyStride once your reports are ready
  • Your DNA data is encrypted and never sold
  • 30-day money-back guarantee

Want the full picture? Get the StrideDNA Optimal Health Test for €239.85, or upgrade later for €117 with no new sample.

Why 18 genes

More than an MTHFR test: every step of methylation

You probably came for MTHFR. Most people do. But your C677T or A1298C result doesn’t mean much on its own. How your folate cycle runs depends on the genes that feed MTHFR and the genes that depend on it.

So this MTHFR test reads both common MTHFR variants alongside 17 other methylation genes, across all five methylation cycles. You see the whole system, not one data point, and so does anyone (or any AI) you share your results with.

Microscope image of cells, greyscale with a green wash MTHFR C677T MTHFR A1298C COMT MTR MAOA
What’s in your report

The 18 methylation genes in your MTHFR and methylation report

Each cycle gets its own report, showing your result for every gene and what it’s linked to.

Your MTHFR result

Folate cycle

Turns folate from food into the active form your cells use.

MTHFR C677TMTHFR A1298CMTHFD1DHFR

Methionine cycle

Recycles homocysteine back into methionine, with B12 and folate.

MTRMTRRBHMTPEMTFUT2TCN2

Transsulphuration

The other route out for homocysteine, towards glutathione.

CBSGSS

BH4 cycle

Links methylation to the enzymes that handle neurotransmitters.

COMTMAOAMAOBVDR

Urea cycle

Connects methylation to nitric oxide and antioxidant enzymes.

NOS3SOD2
Included with this test

Your methylation results, turned into a plan

Most people take their MTHFR result to ChatGPT and ask what to do. Your Stride protocol does that for you, using all 18 genes: it reads your results, connects the ones that relate, and ranks what to focus on first. Every action links back to the gene behind it. Then your specialist goes through it with you in your 1:1 consultation.

AI-powered · included with your €122.85 test
AI protocolYour protocol
GoalMethylation support
Connected findings Your MTHFR C677T result, B12 recycling genes and riboflavin need are linked. Stride has combined them into a single ranked plan.
Folate cycleMethionine cycleMTHFR
1
Eat folate-rich greens and legumes every day
DNA · MTHFR C677T
2
Include riboflavin (B2) sources such as eggs and dairy
DNA · MTHFR
3
Take methylated B vitamins to support your methylation cycles
DNA · MTR, MTRRDNA · TCN2
+3 more actions and a daily practice in your full protocolFull protocol

Illustrative example. AI-generated lifestyle guidance, not medical advice.

Ranked by impactPrioritised by what your 18 genes show matters most for you.
Fully traceableEach action links back to the exact gene behind it.
Yours to use, or notFollow it fully, pick a few actions, or keep it for reference.

AI-generated lifestyle guidance, not medical advice. Paired with a 1:1 consultation with a Stride nutrition specialist. Your data is used only to generate your protocol: never sold, shared or used to train external models.

How it works

How the MTHFR DNA test works

Your genes don’t change, so you only need to take it once.

  1. Opening the Stride DNA test kit
    Step 1

    Order your kit

    Free UK delivery. Kits usually arrive in 1 to 2 working days.

  2. Taking the cheek swab
    Step 2

    Swab your cheek

    No needles, no blood. Just a painless swab inside your cheek.

  3. Packing the swab into the prepaid envelope
    Step 3

    Send it to the lab

    Pop your swab in the prepaid envelope and post it back to our UK lab, where your 18 methylation genes are analysed.

  4. Reading the methylation reports in MyStride on a laptop
    Step 4

    Your reports

    Five reports, one per cycle, plus your AI-powered protocol, in MyStride in about 10 working days.

  5. Video consultation with a Stride nutrition specialist
    Step 5

    Your consultation

    Book a 1:1 video call with a nutrition specialist to talk through your results.

Compare

How Stride compares with other MTHFR tests in the UK

Stride MTHFR & Methylation TestStrideDNA Optimal Health TestThe Ultimate Human test (sold by Healf)Body Fabulous Methylation test
Price€122.85€239.85, or €117 to upgrade£449.10 (on sale from £499)£499£279 for lab results only; £475 with a video call & report
Genes analysed181101378
MTHFR C677T and A1298CNames MTHFR, but not which variantsNames MTHFR, but not which variants
SampleCheek swab at homeCheek swab at home“A small sample” (type not stated)Cheek swab
ResultsAbout 10 working daysAbout 10 working days14 to 21 daysAbout 3 weeks after the lab receives it
1:1 consultationNot stated on the pageOnly in the £405+ packages
Protocol and supplement recommendations“Personalised supplement roadmap”“Supplement guidance”
Upgrade to a full DNA health test without a new sample€117It is the full test: 45 reports

Checked on Healf’s and Body Fabulous’s pages, 29 October 2026.

Upgrade any time

Start with MTHFR. Add the full DNA health test later.

Your swab is read once. Upgrade to the StrideDNA Optimal Health Test whenever you like for €117, and 40 more reports appear in MyStride. No new sample, no new wait.

Today

€122.85

MTHFR & Methylation Test

18 genes · 5 reports · consultation

Whenever you’re ready

+ €117

Upgrade in MyStride, same sample

Total

€239.85

StrideDNA Optimal Health Test

110 genes · 45 reports · consultation

Learn about Optimal Health →
Start with MTHFR today. Upgrade whenever you’re ready.

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At a glance

MTHFR test: the facts

Everything about the MTHFR & Methylation Test in one place.

Sample
DNA cheek swab, taken at home
What’s read
18 genes across five methylation cycles, including both MTHFR variants
MTHFR variants
C677T and A1298C, with copy number (0, 1 or 2)
Lab
Analysed in our UK laboratory
Results
About 10 working days, in MyStride
Protocol
AI-powered, built from all 18 genes and ranked by what to focus on first
Consultation
1:1 video call with a nutrition specialist
Upgrade
To the StrideDNA Optimal Health Test for €117, no new sample
Free gift
4 weeks of MS-01, no subscription unless you choose one
Who it’s for
Anyone who wants to know their MTHFR status and how their methylation genes work together
What it isn’t
A diagnostic or medical screening test, or an epigenetic age test
Your data
Encrypted, pseudonymised, stored in the EEA, never sold. Deleted on request.
Price
€122.85, including the consultation and delivery
FAQ

MTHFR test FAQs

What is the difference between this test and the StrideDNA Optimal Health Test?

This test reads 18 methylation genes, including both MTHFR variants, and gives you 5 reports. The StrideDNA Optimal Health Test reads 110 genes and gives you 45 reports, adding nutrition, fitness, sleep and skin. Both tests include your reports in MyStride, an AI-powered protocol and a 1:1 consultation.

Can I upgrade later?

Yes. Upgrade in MyStride for €117 and your extra reports use the same sample, so there is no new swab and no new wait.

Is this a diagnostic test?

No. It reads gene variants linked to how your body uses folate and B vitamins. It doesn’t diagnose or predict any condition. If you have symptoms, speak to your GP.

I carry an MTHFR variant. Is something wrong?

MTHFR variants are common. One or two copies change how efficiently one enzyme works; they aren’t a diagnosis. Your report shows the result alongside your other 17 genes, and your specialist talks it through with you.

Should I take methylfolate?

Your report and consultation cover which forms of folate and B vitamins suit your results. Check with your GP or pharmacist before starting any supplement, especially if you take medication.

I’ve already done 23andMe. Why take this test?

You don’t need to provide another sample! Our Stride Link service allows you to upload your existing 23andMe raw DNA data and receive personalised Stride DNA reports without another test. You can find out more and get started here.

How long do results take, and what happens to my data?

About 10 working days after the lab receives your swab. Your data is encrypted, pseudonymised and stored in the EEA. It’s never sold, and we delete it on request.

Know your MTHFR result, and the other methylation genes around it.Know your MTHFR result, and the 17 genes around it.

€122.85