Optimal DNA & Methylation Test

Your genes influence how well you process carbs, your insulin sensitivity, and how efficiently you use glucose. Some people are more prone to blood sugar spikes from high-GI foods, increasing the risk of insulin resistance. Knowing your genetic response helps you tailor carb choices to support steady energy, gut health, and long-term metabolic balance.

Genes: ACE, PPARG, TCF7L2, ADRB2, CLOCK, PLIN, INSIG, FTO, FABP2

This panel reveals how your body absorbs and processes fat, especially saturated fat, and how it affects your cholesterol levels. While fats are essential for energy, vitamin absorption, and cell health, some genotypes are more sensitive to saturated fat, raising the risk of high cholesterol and heart disease. Knowing your fat response helps you make smarter, heart-healthy choices.

Genes: APOC3, APOA5, APOA2, LPL, FABP2, FTO, CETP, LEPR, MC4R, PLIN, TCF7L2, PPARG, APOE, LIPC, APOE

Your genes affect how efficiently you convert carotenoids into active vitamin A (retinol), with some people converting up to 60% less. Poor converters need more preformed vitamin A to support vision, immunity, and gene expression. Understanding your genetic efficiency helps ensure you’re meeting your body’s true vitamin A needs.

Genes: BCMO1, BCO1

Riboflavin (vitamin B2) powers key coenzymes involved in energy production, fat metabolism, and detoxification. It also supports healthy homocysteine levels, especially in those with MTHFR variants that reduce enzyme efficiency by up to 65%. If you carry these variants, targeted B-vitamin support can help lower cardiovascular risk and optimise methylation.

Genes: MTHFR (C677T), MTHFR (A1298C)

Vitamin B6 supports over 140 enzyme reactions, including those involved in brain function, blood vessel health, and antioxidant defence. It also helps lower homocysteine, especially important for those with low-functioning MTHFR variants. For these individuals, B6 can play a key role in reducing cardiovascular risk and supporting optimal methylation.

Genes: MTHFR (C677T), NBPF3

Folate is central to one-carbon metabolism, working with B12, B6, and riboflavin to regulate homocysteine and support heart, immune, and brain health. MTHFR variants can reduce folate processing by up to 65%, raising homocysteine and disease risk. Knowing your genetic efficiency helps guide the right form and dose of folate for optimal protection.

Genes: MTHFR (C677T), MTHFR (A1298C), CBS

Vitamin C supports collagen production, hormone synthesis, immunity, and antioxidant defence. But genetic variations in how you absorb and transport vitamin C can leave you with suboptimal levels - even with a good diet. Testing helps identify whether your genes may be limiting this vital nutrient’s impact on your skin, stress response, and long-term health.

Genes: SLC23A1, GSTT1, SOD2

Vitamin B12 powers red blood cell formation, nerve health, and energy production, and plays a vital role in the methylation cycle. Some people have gene variants that reduce B12 absorption and transport, leading to deficiency even with adequate intake. Testing reveals if your genetics are limiting B12 activity and if you need a more bioavailable form or higher intake.

Genes: FUT2, TCN2

Vitamin D supports bone strength, muscle function, immunity, and insulin signalling. But your genetic makeup can affect how well you activate, transport, and respond to it. Variants in genes like VDR and CYP2R1 may mean you need more vitamin D than others to maintain optimal levels. Understanding your genetic profile helps tailor your intake to match your body’s true needs.

Genes: VDR

Vitamin E protects cells from oxidative stress, supports brain and heart health, boosts immunity, and may slow cellular aging. However, genetic differences in absorption and transport can lead to lower circulating levels, even with a good diet. Knowing your genetic profile can uncover hidden needs and help you optimise vitamin E’s protective effects.

Genes: CYP4F2, ZPR1

Iron is vital for oxygen transport, immune defence, and healthy skin, hair, and nails. But certain genetic variants, especially in the HFE gene, can lead to excessive iron absorption and increase the risk of iron overload (hemochromatosis). Identifying these variants can help you manage iron intake and prevent long-term damage from hidden excess.

Genes: HFE

Iron is essential for oxygen transport, immune defence, brain function, and muscle activity. While most focus is on deficiency, some genetic variants – like those in the TMPRSS6 gene – can disrupt how your body regulates iron through hepcidin, affecting absorption and storage. Understanding your genetic control of iron balance helps fine-tune intake and avoid both deficiency and overload.

Genes: TMPRSS6, TFR2, TF

Your antioxidant system defends cells against free radicals, protecting energy levels, thyroid health, immunity, and insulin sensitivity. But genetic differences in key detox enzymes can weaken this defence, raising the risk of chronic diseases. Identifying these variants reveals whether your body needs extra support from diet or lifestyle to boost resilience.

Genes: CAT, GPX1, SOD2

Omega-3s help lower chronic inflammation and support brain, eye, and nerve health. But your genes affect how well you convert ALA and EPA into DHA – the most active form. If you're a poor converter, you may need more DHA from diet or supplements to meet your body’s needs and boost resilience.

Genes: IL6, TNF

The LCT gene controls your ability to produce lactase – the enzyme needed to digest lactose in dairy. While most people lose this ability after infancy, some have a genetic trait called lactase persistence, allowing them to tolerate dairy into adulthood. Knowing your LCT status helps you understand whether dairy is a friend or foe to your digestion.

Genes: LCT/MCM6

Gluten is a protein found in wheat, barley, and rye but certain HLA gene variants can trigger an immune reaction to it, increasing your risk of Coeliac disease. These genes influence how your immune system responds in the gut. Knowing your HLA status can clarify whether gluten may be harming your health behind the scenes.

Genes: HLA DQ2/DQ8

Fructose is a natural sugar found in fruit, but variants in the ALDOB gene can impair its metabolism, leading to hereditary fructose intolerance. This can cause nausea, bloating, and discomfort after eating fructose-containing foods. Identifying ALDOB mutations helps explain unexplained digestive symptoms and guides smarter food choices.

Genes: ALDOB

While the body needs some salt for muscle and fluid balance, certain genetic variants can make you more sensitive to sodium – raising your risk of high blood pressure, heart disease, and stroke. Knowing your salt sensitivity helps you take proactive steps to protect your cardiovascular health.

Genes: ACE, AGT

The ADH1C gene influences how your body breaks down alcohol. Some variants produce a slower-acting enzyme, which is linked to higher HDL (“good”) cholesterol levels in moderate drinkers. While this doesn’t affect alcohol tolerance, it can reveal how your genetics shape the impact of alcohol on heart health.

Genes: ADH1C

Your response to caffeine is shaped by your genetics – specifically how quickly your body breaks it down. Fast metabolisers may handle caffeine well, while slow metabolisers are more likely to experience anxiety, sleep issues, and cardiovascular effects. Knowing your caffeine metabolism can help you tailor your intake for better focus, energy, and long-term health.

Genes: CYP1A2

High-heat cooking of meats can produce harmful compounds like HCAs and PAHs, which damage cells through oxidative stress. Your genes influence how efficiently your body detoxifies these compounds. Certain variants may slow this process, increasing your risk of long-term cellular damage. Understanding your genetic detox capacity can guide safer cooking and dietary choices.

Genes: CYP1A2, EPHX1

Phase II detox relies on enzymes like GSTM1 to neutralise harmful compounds in the liver. Some people carry a deleted version of the GSTM1 gene, meaning this key enzyme is missing – reducing detox capacity. If you have this variant, increasing your intake of cruciferous vegetables can help support your body’s natural detox pathways.

Genes: GSTM1, GSTT1

Excess sugar can lead to fatigue, brain fog, and long-term health issues. A specific genetic variant influences how your body regulates blood glucose and how strongly you crave sweet foods. Carriers of this variant may consume more sugar and face a higher risk of cavities and metabolic imbalances. Knowing your sugar response can help you take control of cravings and protect your health.

Genes: GLUT2

Your ability to taste bitterness is influenced by the TAS2R38 gene, which encodes a receptor that detects bitter compounds in foods like broccoli and brussels sprouts. People with certain variants are “supertasters” and may find these foods more intense or unpleasant. Knowing your taste genetics can help explain food preferences – and guide strategies for improving dietary variety.

Genes: TAS2R38

Your genetic chronotype shapes your internal body clock - determining when you naturally feel most alert or sleepy. It influences your energy patterns, hormone cycles, and even workout or productivity timing. By analysing multiple genes linked to circadian rhythm, we can identify whether you're more of a morning lark or a night owl, helping you align your lifestyle with your biology.

Genes: RNASEL, VIP, PER3, PER2, RASD1, FBLX3, PLCL1, RGS16, HCRTR2

Sleep is essential for mental and physical recovery but how easily you fall and stay asleep can be influenced by your genes. Variants in genes like ADA and MEIS1 affect sleep depth, efficiency, and sensitivity to disturbances. Understanding your genetic sleep profile can help you optimise rest, manage stress, and improve overall wellbeing.

Genes: ADA, MEIS1

Caffeine keeps you alert by blocking adenosine, the chemical that builds sleep pressure in your brain. But certain variants in the ADORA2A gene can make you more sensitive to caffeine’s effects - leading to disrupted sleep or insomnia, especially if consumed late in the day. Your genetic profile helps determine how caffeine affects your sleep and circadian rhythm.

Genes: ADORA2A

Your body’s response to stress is driven by hormones like cortisol and adrenaline but how you process stress is also shaped by your genes. Variants in key genes can influence dopamine sensitivity, emotional regulation, and how resilient you are under pressure. Understanding your genetic stress profile helps you manage triggers more effectively and build long-term resilience.

Genes: XKR6, MIR2113, BDNF, COMT, DCAF5, FKBP5, HTR2A, LINCOO461, NOS1, OXTR

The COMT gene influences how quickly your brain clears dopamine during stress, shaping how well you perform under pressure. Fast metabolisers tend to stay calm in high-threat situations, while slow metabolisers may excel in complex, detail-heavy tasks. Your COMT type can help explain your natural stress tolerance and the environments where you thrive best.

Genes: COMT