Gary Brecka Methylation Test vs. Stride DNA

What 10,000 Results Reveal About Your Health

Methylation tests are exploding in popularity, thanks in part to wellness figures like Gary Brecka and companies like Stride DNA. But what exactly are these tests, and what can they reveal about your health?

At Stride, we’ve analysed results from over 10,000 customers — and the findings are eye-opening. Almost everyone shows at least one inefficiency in the way their body methylates. Here’s what that means for you, and how the Stride Methylation Test compares with Brecka’s approach.

What Is a Methylation Test?

Methylation is one of the body’s most important biochemical processes. It’s how your body transfers “methyl groups” (tiny chemical tags) to DNA, proteins, and neurotransmitters. This influences:

• How well you produce energy
• How you detoxify
• How your brain regulates mood
• How your cells repair themselves

And the bad news: When methylation isn’t working properly, you may be more prone to fatigue, mood swings, high homocysteine, and even cardiovascular or fertility issues.

A methylation DNA test looks at your genes — specifically SNPs (single nucleotide polymorphisms) — in the pathways that control these reactions. At Stride, that means analysing 37+ genes across five key pathways:

• Folate Cycle
• Methionine Cycle
• Transsulphuration Pathway
• BH4 Cycle
• Urea Cycle

We’ll explain these pathways for you in a second. Sit tight.

The Big Reveal — What 10,000 Stride DNA Results Show

We analysed the results from 10,000 Stride Methylation Tests, one thing stood out: almost everyone had at least one inefficiency.

Here’s what the data shows — and why it matters:

• Methionine Cycle (85% impaired): This pathway helps control homocysteine (a cardiovascular risk marker) and makes SAMe, a compound vital for mood, detox, and DNA repair. When impaired, it can mean higher heart risk, mood changes, and lower energy.
• BH4 Cycle (53% impaired): Responsible for producing key neurotransmitters like dopamine and serotonin, this pathway strongly influences mood, motivation, sleep, and focus.
• Folate Cycle (~40% impaired): Folate (vitamin B9) is central to DNA repair, pregnancy health, and energy production. Only about 2% of people had fully “normal” folate and BH4 function.
• Transsulphuration Pathway (12% impaired): Produces glutathione, your body’s master antioxidant, which protects against oxidative stress and toxins.
• Urea Cycle (18% impaired): Helps your body eliminate ammonia and supports cardiovascular health by regulating nitric oxide.

In other words, methylation testing isn’t about chasing “optimal” performance — it’s about uncovering hidden inefficiencies that could be silently affecting your energy, mood, resilience, and long-term health.

How Can You Support Methylation?

You can’t change your genes — but you can support them. One of the most effective strategies is to use methylated vitamins. Think of these like pre-digested (or pre-methylated) vitamins that are already in their active form and don’t rely on slow or faulty pathways.

Here’s how that works for each pathway:

• Folate Cycle inefficiencies → Standard folic acid may not be well-converted, but methylfolate (5-MTHF) bypasses this block.
• Methionine Cycle inefficiencies → Support with methylcobalamin (B12) and methylfolate improves homocysteine balance and SAMe production.
• BH4 Cycle inefficiencies → Often helped by B2 (riboflavin), B6 (pyridoxal-5-phosphate), antioxidants, and methyl donors.
• General support → A methylated B-complex (B9, B12, B2, B6) plus cofactors like zinc, magnesium, choline, and betaine can help optimise these cycles.

Lifestyle choices also matter. If you’re deficient on any of these pathways, you can choose to eat more of the following:

• Leafy greens, eggs, and beetroot for folate, choline, and betaine.
• Fish, meat, and dairy for vitamin B12 and B2.
• Resistance training to buffer ammonia and support the Urea Cycle.
• Antioxidants from colourful fruits and vegetables to reduce oxidative stress.
• Gut health support with probiotics and fibre for better nutrient absorption.

Reviews and Comparisons — Stride vs Gary Brecka

Searches for Gary Brecka methylation test dominate Google right now. Brecka, known for his work with 10X Health, has popularised methylation testing through a celebrity and performance-driven lens.

Stride takes a different approach:

• UK-based, science-first → 10,000+ real customer results tell us that customers love what we do.
• Clinician-reviewed reports → each pathway explained with gene-by-gene results.
• Actionable advice → not just “you have a mutation,” but tailored nutrition and testing recommendations and supplements, including MS-01.
• Accessible → for anyone in the UK looking for the best genetic methylation test.

If you’ve searched “Stride methylation test reviews” or “genetic methylation test UK,” this is where the data makes a difference. 

Should You Get a Methylation Test?

Whether you’ve heard about methylation through Gary Brecka, or you’re exploring the best DNA methylation test in the UK, the evidence is clear:

• The majority of people have inefficiencies in one or more pathways.
• Knowing your genetic profile allows you to take targeted action — from choosing the right methylated vitamins to optimising diet, exercise, and lifestyle.
• A simple DNA test provides long-term insight into areas of weakness you can support for better energy, mood, and resilience.

That’s a Wrap

Methylation is the hidden switchboard of your biology. Stride’s dataset proves that inefficiencies are the rule, not the exception.

So if you’ve been wondering whether a methylation test is worth it, the answer is simple. Order a test today.

Order Your Stride Methylation Test