Menu
-
Shop All
Contact
hey@getstride.com
Stride Health Group
Stride Health Group Ltd
Company No 05158025
Lamas Road
Badersfield
Norwich
England
NR10 5FB
UK
DNA Tests
Core Genetic Methylation Test
Excellent
Rated 4.9 out of 5
(383 Reviews)
The Stride Core DNA & Methylation Test analyses 19 key genes across essential methylation pathways, including MTHFR, MTRR, MAOA and COMT. It shows how efficiently your body methylates and uses critical nutrients like folate and other B vitamins, ideal if you want a simple starting point and clear answers around low energy, mood or nutrient deficiencies.
Using a simple at-home cheek swab, this one-time test delivers focused, easy-to-understand insights you can use for life. If you want deeper guidance beyond methylation alone, our Advanced and Optimal tests offer broader nutritional and lifestyle insights.
What's included :
- Analyse five key methylation pathways (folate, methionine, transsulphuration, BH4, urea)
- Understand genetic factors that influence detox, neurotransmitters, and energy production
- Personalised nutrition + supplement guidance based on variants incl. MTHFR and COMT
- Includes 1:1 consultation to interpret results and next steps
- Cheek swab at home, results in 10 working days
- In-house accredited laboratory
Choose your test level.
Not everyone is looking for the same insights, so our DNA test comes in 3 levels, Optimal, Advanced and Core.
Secure, private platform
30-day money-back guarantee
As featured in
50%+
of adults have genetic variations disrupting methylation, the process that controls mood, detox, and hormone balance.
Constant fatigue
Low mood / stress
Hormonal imbalance
Slow recovery
How It Works
Here’s how your DNA test works
Simple, fast, and science-backed, your journey to better health in three easy steps.
Step 1
Order your kit
Delivered in 1–2 days
Step 2
Provide your DNA sample
Easy at-home self-collection
Step 3
In-house lab testing
Private and secure analysis <10 days
Step 4
Get your personalised report
45+ insights with expert guidance
Science
Stride methylation test: How your biology speaks to you
Methylation is a core control system in the body. It helps regulate how you produce energy, clear waste, repair cells, and stay resilient over time. The Stride DNA & Methylation Test shows how well this system is likely to work for you — and how to support it.
1. What is methylation?
A control system that helps your body run properly
Methylation is a natural process that helps your body decide what to do, when to do it, and how well to do it. It works like a set of switches inside your cells, turning key processes up or down as needed — including energy production, detoxification, repair, and recovery.
The Stride DNA & Methylation tests focus on the main methylation cycles, starting with how your body converts folate (vitamin B9) into its usable form — a step that unlocks many other important processes.
What exactly is being “switched”?
Small markers (called methyl groups) are added to parts of your DNA and other molecules. They don’t change who you are — they simply help your body prioritise what needs attention.
Does methylation change my genes?
No. Your genes stay the same. But your DNA can show how efficiently your methylation cycles are working, helping you make better health decisions.
Is methylation fixed for life?
No. It can change over time and responds to factors like nutrition, stress, environment, and ageing.
2. Why methylation matters
Because many core body systems rely on it
When methylation is working well, your body is better at producing energy, clearing toxins, repairing cells, and staying resilient as you age.
When it’s under strain, people may notice fatigue, slower recovery, inflammation, or feeling generally “out of sync”. Changes in methylation are commonly linked to ageing and long-term health issues.
How does this affect detox and repair?
Methylation helps your body neutralise waste products and repair everyday cellular damage. If this system is overloaded or inefficient, things can start to back up.
What happens if methylation isn’t working well?
Your body may struggle to keep up with repair and regulation, which can contribute to low energy, inflammation, and faster biological ageing over time.
Can I influence methylation myself?
Yes. Nutrition (especially methylated B-vitamins), lifestyle, stress levels, and environmental exposure all play a role.
3. How Stride helps you
Clear insight, then clear next steps
The Stride Optimal DNA & Methylation test looks at how well your methylation cycles are likely to function, based on your genetics.
We don’t just give you raw data. We translate your results into practical guidance, helping you understand where your body may need extra support.
What does the test actually show me?
It highlights genetic patterns linked to how efficiently your methylation cycles work, and where your body may benefit from extra support.
What do I do with the results?
You’ll receive clear recommendations and a complimentary 1:1 expert consultation. This covers nutrition, supplements (if needed), and simple lifestyle adjustments tailored to you.
How is this different from a standard DNA test?
Many DNA tests stop at information. Stride focuses on interpretation and action — turning complex biology into practical steps you can actually use.
Reports
Methylation is just one part of the picture
Stride gives you a wider view of your health, with clear reporting across multiple key systems — all delivered in MyStride with expert guidance and actionable next steps.
Methylation Profile
Understand how your folate, methionine, BH4, and transsulphuration cycles are wired.
Helps with: DNA repair, detox, neurotransmitters, energy.
Includes: 5 reports
Nutrition
See how your genes shape vitamin/mineral needs and carb/fat handling.
Helps with: intake, intolerances, better absorption.
Includes: 24 reports
Fitness
Train the way your body responds best. Avoid wasted effort and plateaus.
Helps with: intensity, recovery, injury risk, programming.
Includes: 4 reports
Sleep & Stress
Work with your natural rhythm and resilience. Wake restored; stay calm daily.
Helps with: chronotype, sleep quality, coping under stress.
Includes: 5 reports
Skin
Target what your skin actually needs. Personalised care for visible results.
Helps with: DNA repair, detox, neurotransmitters, energy.
Includes: 5 reports
What reports and genes are included?
Methylation
Folate Cycle (5 genes)
The Folate Cycle converts dietary folate into usable forms for critical bodily processes. Understanding your genetic predispositions is crucial because variations like impaired MTHFR or DHFR function can significantly reduce folate processing efficiency.
Genes: DHFR, MTHFD1, MTHFR (A1298C), MTHFR (C677T)
Methionine Cycle (6 genes)
The Methionine Cycle drives methylation by producing SAMe - vital for gene expression, detox, and brain chemistry. Variants here can raise homocysteine and stall key pathways like BH4 and Transsulphuration. A methylation panel can uncover blocks behind fatigue, poor focus, and hormonal imbalance.
Genes: MTR, MTRR, FUT2, TCN2, PEMT, BHMT
The Transsulphuration Pathway (2 genes)
This pathway clears homocysteine by turning it into cysteine - fuel for glutathione and taurine. Genetic blocks here can impair detox, raise sulphite toxicity, and drive brain fog and burnout. Screening for these variants can reveal why your stress and recovery systems are under strain.
Genes: CBS (C699T), GSS
The BH4 Cycle (4 genes)
The BH4 Cycle makes key neurotransmitters like dopamine and serotonin and supports nitric oxide and thyroid function. It depends on folate and SAMe from other cycles. Variants can lead to mood issues, poor sleep, and low motivation. Knowing your BH4 profile helps explain and address deeper neurological imbalances.
Genes: MTHFR (A1298C), COMT, VDR, MAOA, MAOB
Urea Cycle (2 genes)
The Urea Cycle detoxifies ammonia by converting it into urea for safe excretion - a vital process linked to liver function, nitrogen balance, and brain health. It also produces arginine, needed for nitric oxide (NO), which supports blood flow and protects your heart. Variants here or low BH4 can impair NO production, increasing oxidative stress and cardiovascular risk.
Genes: NOS3, SOD2
US VS THEM
Why smart optimisers choose Stride
Get faster results, deeper insights, and real guidance, not just data. Here’s how Stride stacks up.
| Stride Core DNA Methylation Test | 10x Health System | Ultimate Human | |
|---|---|---|---|
| Genes analysed | 19 | 5 | 13 |
| Results time | 10 days | 4 weeks | 5 weeks |
| 1:1 Expert consultation |  |
 |
|
| Personalised plan | |
|
|
| Money-back guarantee | |
|
|
| Price | $160.30 | £499 | $599 |
| Buy Now |
Why test DNA methylation with Stride?
Deeper Analysis
Most methylation tests on the market look at only a handful of genetic variants. StrideDNA analyse more than 9,000 genetic locations with every sample for the most precision picture of your health.
Data Security
We use strong technical and organisational measures to keep your data safe. It is stored securely and encrypted, and only accessible by the minimum necessary members of our team.
Expert Support
Forget hard to understand lab reports on a static PDF, with no support. StrideDNA results are delivered in your own interactive, world-class portal and every test includes 1:1 support from our expert team of human health practitioners.
Faster turnaround
Unlike almost every other test provider, we own and operate our own in-house laboratory here in the UK. This means we can be higher quality, lower cost and deliver results faster than anyone else.
For the curious.
What is a genetic methylation test?
A genetic methylation test analyses key genes involved in the body’s methylation pathways, which support detoxification, neurotransmitter balance, hormone regulation, and energy production.
The Stride Core Methylation Test is an at-home genetic test that examines DNA variants affecting five core methylation cycles, providing clear, actionable insights rather than raw genetic data.
Why is methylation important for health, and how do genetic variants affect it?
Methylation is a core biochemical process that supports gene expression, detoxification, energy production, immune function, neurotransmitter balance, and lipid metabolism.
Genetic variants in methylation-related genes (e.g., MTHFR, MTR, MTRR, COMT, BHMT, CBS) can influence how efficiently your body converts and uses nutrients such as folate and B12, which may affect energy, mood, cardiovascular and neurological health.
Understanding your variants helps tailor nutrition and supplementation (e.g., folate form and dose, B-vitamin support), alongside lifestyle changes to optimise methylation.
What's included with the Core Methylation Test?
Your kit includes:
- Easy-to-use at-home DNA test kit
- Free return mailer to our UK laboratory
- 5 Methylation Reports: Folate Cycle, Methionine Cycle, Transsulphuration Pathway, BH4 Cycle, Urea Cycle
- 1:1 Health Expert Support (including dietician)
- Access to the Stride digital health platform
What methylation pathways does it analyse?
The Core Methylation Test covers the Folate Cycle, Methionine Cycle, Transsulphuration Pathway, BH4 Cycle, and Urea Cycle to help you understand where methylation efficiency may be supported.
What genes are analysed in a genetic methylation test?
This genetic methylation test analyses over 9,000 genetic locations, focusing on variants with strong scientific evidence that influence methylation efficiency.
Key genes include MTHFR, COMT, MTR, MTRR, CBS, and others involved in folate metabolism, neurotransmitter balance, and detoxification pathways.
Why is the AHCY gene not included in Stride's Methylation Report?
We include genes with strong human evidence and clear, modifiable actions.
AHCY SNPs rs41301825 and rs13043752 are regarded as benign and rare; rs121918608 is a very rare pathogenic mutation. Including benign or ultra-rare variants would not add meaningful, actionable insight for most users.
How does the Core Methylation Test differ from other DNA tests?
Stride analyses more genetic locations than most methylation-only tests and delivers results via an interactive platform with expert support, helping you translate data into practical nutrition and supplement strategies.
How can this test benefit my health?
It identifies potential inefficiencies in methylation that can affect energy, detoxification, immune function, neurotransmitters, and nutrient conversion (e.g., folate), guiding targeted diet and supplement choices.
What kind of support do I receive with my StrideDNA Test?
Every Stride test includes 1:1 consultations with qualified dieticians and health practitioners. Our experts interpret your results and help you build a personalised plan.
How long does it take to receive my results?
Your results are typically available within 10 business days after your sample arrives at our UK laboratory.
Where can I get a genetic methylation test?
You can order this genetic methylation test online for at-home use. Stride ships test kits from its UK-based laboratory and accepts samples returned by post.
The test is available across the UK and internationally, with all samples analysed in Stride’s accredited in-house laboratory.
Can I take this test if I’m under 18?
StrideDNA tests are designed for adults (18+).
If you are under 18, testing should only be arranged by a parent or legal guardian, and ideally interpreted with a qualified healthcare professional. Regulatory rules and availability for minors can vary by country.
If you’re unsure, email hey@getstride.com and we’ll advise before you order.