Menu
-
Shop All
Contact
hey@getstride.com
Stride Health Group
Stride Health Group Ltd
Company No 05158025
Lamas Road
Badersfield
Norwich
England
NR10 5FB
UK
DNA Tests
DNA & Methylation Test
Excellent
Rated 4.9 out of 5
(410 Reviews)
The Stride DNA & Methylation Test shows how efficiently your body methylates and uses key nutrients like folate and other B vitamins, with insight into genes such as MTHFR, MTR, MAOA and COMT. Choose from three levels, then compare what each one covers below.
- 1:1 expert consultation included with every level
- Simple at-home cheek swab, results in 10 working days
- Analysed at accredited specialist laboratories
Choose your test level.
Not everyone is looking for the same insights, so our DNA test comes in 3 levels, Optimal, Advanced and Core.
Compare levels
What's included at each level
Every level analyses your core methylation pathways. Higher levels add more of your genetic picture, from nutrition to fitness, sleep and stress.
| Core | Advanced | Optimal Most popular | |
|---|---|---|---|
| Best for | A clear starting point, focused on methylation | Methylation plus deeper nutrition insight | The complete picture across your biology |
| Genes analysed | 19 | 59 | 110 |
| Methylation pathways (folate, methionine, BH4, urea, transsulphuration) |  |
|
|
| Nutrition & metabolism insights |  |
|
|
| Fitness, sleep & stress insights | |
|
|
| 1:1 expert consultation | |
|
|
| At-home cheek swab, results in 10 days | |
|
|
| Price | €132 | €223 | €307 |
| Add to Cart | Add to Cart | Add to Cart |
As featured in
110
genes behind your methylation cycles — including MTHFR, MTR, COMT and BHMT — analysed to give you a clear picture of how your body is wired to process key nutrients linked to energy, focus and recovery.
Folate and B-vitamin processing
Methylation pathway efficiency
Personalised nutrition guidance
1:1 expert consultation included
How It Works
Here’s how your DNA test works
Simple, fast, and science-backed, your journey to better health in three easy steps.
Step 1
Order your kit
Delivered in 1–2 days
Step 2
Provide your DNA sample
Easy at-home self-collection
Step 3
Accredited specialist lab
Private and secure analysis <10 days
Step 4
Get your personalised report
45+ insights with expert guidance
Science
Stride methylation test: How your biology speaks to you
Methylation is a core control system in the body. It helps regulate how you produce energy, clear waste, repair cells, and stay resilient over time. The Stride DNA & Methylation Test shows how well this system is likely to work for you, and how to support it.
1. What is methylation?
A control system that helps your body run properly
Methylation is a natural process that helps your body decide what to do, when to do it, and how well to do it. It works like a set of switches inside your cells, turning key processes up or down as needed, including energy production, detoxification, repair, and recovery.
The Stride DNA & Methylation tests focus on the main methylation cycles, starting with how your body converts folate (vitamin B9) into its usable form, a step that unlocks many other important processes.
What exactly is being “switched”?
Small markers (called methyl groups) are added to parts of your DNA and other molecules. They don’t change who you are. They simply help your body prioritise what needs attention.
Does methylation change my genes?
No. Your genes stay the same. But your DNA can show how efficiently your methylation cycles are working, helping you make better health decisions.
Is methylation fixed for life?
No. It can change over time and responds to factors like nutrition, stress, environment, and ageing.
2. Why methylation matters
Because many core body systems rely on it
When methylation is working well, your body is better at producing energy, clearing toxins, repairing cells, and staying resilient as you age.
When it’s under strain, people may notice fatigue, slower recovery, inflammation, or feeling generally “out of sync”. Changes in methylation are commonly linked to ageing and long-term health issues.
How does this affect detox and repair?
Methylation helps your body neutralise waste products and repair everyday cellular damage. If this system is overloaded or inefficient, things can start to back up.
What happens if methylation isn’t working well?
Your body may struggle to keep up with repair and regulation, which can contribute to low energy, inflammation, and faster biological ageing over time.
Can I influence methylation myself?
Yes. Nutrition (especially methylated B-vitamins), lifestyle, stress levels, and environmental exposure all play a role.
3. How Stride helps you
Clear insight, then clear next steps
The Stride DNA & Methylation Test looks at how well your methylation cycles are likely to function, based on your genetics.
We don’t just give you raw data. We translate your results into practical guidance, helping you understand where your body may need extra support.
What does the test actually show me?
It highlights genetic patterns linked to how efficiently your methylation cycles work, and where your body may benefit from extra support.
What do I do with the results?
You’ll receive clear recommendations and a complimentary 1:1 expert consultation. This covers nutrition, supplements (if needed), and simple lifestyle adjustments tailored to you.
How is this different from a standard DNA test?
Many DNA tests stop at information. Stride focuses on interpretation and action, turning complex biology into practical steps you can actually use.
Reports
Methylation is just one part of the picture
Stride gives you a wider view of your health, with clear reporting across multiple key systems, all delivered in MyStride with expert guidance and actionable next steps.
Methylation Profile
Understand how your folate, methionine, BH4, and transsulphuration cycles are wired.
Helps with: DNA repair, detox, neurotransmitters, energy.
Includes: 5 reports
Nutrition
See how your genes shape vitamin/mineral needs and carb/fat handling.
Helps with: intake, intolerances, better absorption.
Includes: 24 reports
Fitness
Train the way your body responds best. Avoid wasted effort and plateaus.
Helps with: intensity, recovery, injury risk, programming.
Includes: 4 reports
Sleep & Stress
Work with your natural rhythm and resilience. Wake restored; stay calm daily.
Helps with: chronotype, sleep quality, coping under stress.
Includes: 5 reports
Skin
Target what your skin actually needs. Personalised care for visible results.
Helps with: DNA repair, detox, neurotransmitters, energy.
Includes: 5 reports
What reports & genes are included?
Methylation
Folate Cycle (5 genes)
The Folate Cycle converts dietary folate into usable forms for critical bodily processes. Understanding your genetic predispositions is crucial because variations like impaired MTHFR or DHFR function can significantly reduce folate processing efficiency.
Genes: DHFR, MTHFD1, MTHFR (A1298C), MTHFR (C677T)
Methionine Cycle (6 genes)
The Methionine Cycle drives methylation by producing SAMe - vital for gene expression, detox, and brain chemistry. Variants here can raise homocysteine and stall key pathways like BH4 and Transsulphuration. A methylation panel can uncover blocks behind fatigue, poor focus, and hormonal imbalance.
The Transsulphuration Pathway (2 genes)
This pathway clears homocysteine by turning it into cysteine - fuel for glutathione and taurine. Genetic blocks here can impair detox, raise sulphite toxicity, and drive brain fog and burnout. Understanding these variants can offer insight into how your stress and recovery systems are wired.
Genes: CBS (C699T), GSS
The BH4 Cycle (4 genes)
The BH4 Cycle makes key neurotransmitters like dopamine and serotonin and supports nitric oxide and thyroid function. It depends on folate and SAMe from other cycles. Variants can lead to mood issues, poor sleep, and low motivation. Knowing your BH4 profile helps explain and address deeper neurological imbalances.
Genes: MTHFR (A1298C), COMT, VDR, MAOA, MAOB
Urea Cycle (2 genes)
The Urea Cycle detoxifies ammonia by converting it into urea for safe excretion - a vital process linked to liver function, nitrogen balance, and brain health. It also produces arginine, needed for nitric oxide (NO), which supports blood flow and protects your heart. Variants here or low BH4 can impair NO production, increasing oxidative stress and cardiovascular risk.
Genes: ADNOS3, SOD2ORA2A
Nutrition
Carbohydrate Sensitivity (9 genes)
Your genes influence how well you process carbs, your insulin sensitivity, and how efficiently you use glucose. Some people are more prone to blood sugar spikes from high-GI foods, increasing the risk of insulin resistance. Knowing your genetic response helps you tailor carb choices to support steady energy, gut health, and long-term metabolic balance.
Genes: ACE, PPARG, TCF7L2, ADRB2, CLOCK, PLIN, INSIG, FTO, FABP2
Saturated Fat Sensitivity (15 genes)
This panel reveals how your body absorbs and processes fat, especially saturated fat, and how it affects your cholesterol levels. While fats are essential for energy, vitamin absorption, and cell health, some genotypes are more sensitive to saturated fat, raising the risk of high cholesterol and heart disease. Knowing your fat response helps you make smarter, heart-healthy choices.
Genes: APOC3, APOA5, APOA2, LPL, FABP2, FTO, CETP, LEPR, MC4R, PLIN, TCF7L2, PPARG, APOE, LIPC, APOE
Vitamin A (2 genes)
Your genes affect how efficiently you convert carotenoids into active vitamin A (retinol), with some people converting up to 60% less. Poor converters need more preformed vitamin A to support vision, immunity, and gene expression. Understanding your genetic efficiency helps ensure you’re meeting your body’s true vitamin A needs.
Vitamin B2 (2 genes)
Riboflavin (vitamin B2) powers key coenzymes involved in energy production, fat metabolism, and detoxification. It also supports healthy homocysteine levels, especially in those with MTHFR variants that reduce enzyme efficiency by up to 65%. If you carry these variants, targeted B-vitamin support can help lower cardiovascular risk and optimise methylation.
Genes: MTHFR (C677T), MTHFR (A1298C)
Vitamin B6 (2 genes)
Vitamin B6 supports over 140 enzyme reactions, including those involved in brain function, blood vessel health, and antioxidant defence. It also helps lower homocysteine, especially important for those with low-functioning MTHFR variants. For these individuals, B6 can play a key role in reducing cardiovascular risk and supporting optimal methylation.
Genes: MTHFR (C677T), NBPF3
Vitamin B9 (3 genes)
Folate is central to one-carbon metabolism, working with B12, B6, and riboflavin to regulate homocysteine and support heart, immune, and brain health. MTHFR variants can reduce folate processing by up to 65%, raising homocysteine and disease risk. Knowing your genetic efficiency helps guide the right form and dose of folate for optimal protection.
Genes: MTHFR (C677T), MTHFR (A1298C), CBS
Vitamin C (3 genes)
Vitamin C supports collagen production, hormone synthesis, immunity, and antioxidant defence. But genetic variations in how you absorb and transport vitamin C can leave you with suboptimal levels - even with a good diet. Testing helps identify whether your genes may be limiting this vital nutrient’s impact on your skin, stress response, and long-term health.
Vitamin B12 (2 genes)
Vitamin B12 powers red blood cell formation, nerve health, and energy production, and plays a vital role in the methylation cycle. Some people have gene variants that reduce B12 absorption and transport, leading to deficiency even with adequate intake. Testing reveals if your genetics are limiting B12 activity and if you need a more bioavailable form or higher intake.
Vitamin D (1 gene)
Vitamin D supports bone strength, muscle function, immunity, and insulin signalling. But your genetic makeup can affect how well you activate, transport, and respond to it. Variants in genes like VDR and CYP2R1 may mean you need more vitamin D than others to maintain optimal levels. Understanding your genetic profile helps tailor your intake to match your body’s true needs.
Genes: VDR
Vitamin E (2 genes)
Vitamin E protects cells from oxidative stress, supports brain and heart health, boosts immunity, and may slow cellular aging. However, genetic differences in absorption and transport can lead to lower circulating levels, even with a good diet. Knowing your genetic profile can uncover hidden needs and help you optimise vitamin E’s protective effects.
Iron Regulation (1 gene)
The HFE gene influences how your body absorbs and stores iron. Knowing your variant helps inform how much dietary iron suits you and whether you'd benefit from monitoring iron intake more closely.
Genes: HFE
Iron Absorption (3 genes)
Iron is essential for oxygen transport, immune defence, brain function, and muscle activity. Some genetic variants – like those in the TMPRSS6 gene – influence how your body regulates iron through hepcidin, affecting absorption and storage. Understanding your genetic control of iron balance helps fine-tune dietary intake.
Antioxidants (3 genes)
Your antioxidant system defends cells against free radicals, protecting energy levels, thyroid health, immunity, and insulin sensitivity. But genetic differences in key detox enzymes can weaken this defence, raising the risk of chronic diseases. Identifying these variants reveals whether your body needs extra support from diet or lifestyle to boost resilience.
Omega 3 (2 genes)
Lactose Intolerance (1 gene)
The LCT gene controls your ability to produce lactase...
Genes: LCT/MCM6
Gluten Response (1 gene)
The HLA DQ2/DQ8 genotype influences how your body responds to gluten-containing foods. Knowing your variant helps inform dietary choices.
Genes: HLA DQ2/DQ8
Fructose Intolerance (1 gene)
Fructose is a natural sugar found in fruit...
Genes: ALDOB
Alcohol Response (1 gene)
The ADH1C gene influences how your body breaks down alcohol...
Genes: ADH1C
Caffeine Sensitivity (1 gene)
Your response to caffeine is shaped by your genetics...
Genes: CYP1A2
Detoxification Phase I - Toxin Generation Speed (2 genes)
Detoxification Phase II - Cruciferous Vegetable Needs (2 genes)
Sugar Preferences (1 gene)
Excess sugar can lead to fatigue...
Genes: GLUT2
Bitter Taste Perception (1 gene)
Your ability to taste bitterness is influenced...
Genes: TAS2R38
Fitness
Training Intensity Response (14 genes)
Your genes play a key role in how you respond to different types of exercise - whether you’re better suited to power-based or endurance-focused training. Matching your workouts to your genetic profile can dramatically boost results, with studies showing up to three times greater improvement when training is aligned to your DNA.
Genes: ADRB2, CRP, COL5A1, TRHR, BDKRB2, IL6, ACTN3, VEGF, PPARA, ACE, AGT, NRF, VDR, PPARGC1A
Aerobic Training Response (4 genes)
VO₂max is a key measure of aerobic fitness, reflecting how efficiently your body uses oxygen during exercise. Genetics play a strong role in your capacity to improve VO₂max with training - some people respond more dramatically than others. Knowing your genetic potential helps tailor your fitness approach and set realistic goals.
Recovery Efficiency (7 genes)
Your recovery rate is influenced by how well your body manages oxidative stress and inflammation after exercise. Genetic variants in key detox and inflammatory genes can slow recovery, making you more prone to fatigue, soreness, and overtraining. Understanding your recovery profile helps optimise rest, reduce injury risk, and get more from every workout.
Injury Predisposition (7 genes)
Your genes influence how well your body repairs connective tissue and manages inflammation - two key factors in injury risk. Variants in genes like COL1A1, CRP, and TNF can affect how resilient your joints and tendons are under stress. Knowing your genetic risk helps you train smarter, recover better, and prevent avoidable injuries.
Sleep
Chronotype (9 genes)
Your genetic chronotype shapes your internal body clock - determining when you naturally feel most alert or sleepy. It influences your energy patterns, hormone cycles, and even workout or productivity timing. By analysing multiple genes linked to circadian rhythm, we can identify whether you're more of a morning lark or a night owl, helping you align your lifestyle with your biology.
Genes: RNASEL, VIP, PER3, PER2, RASD1, FBLX3, PLCL1, RGS16, HCRTR2
Sleep Quality (2 genes)
Sleep is essential for mental and physical recovery but how easily you fall and stay asleep can be influenced by your genes. Variants in genes like ADA and MEIS1 affect sleep depth, efficiency, and sensitivity to disturbances. Understanding your genetic sleep profile can help you optimise rest, manage stress, and improve overall wellbeing.
Caffeine & Sleep Response (1 gene)
Caffeine keeps you alert by blocking adenosine, the chemical that builds sleep pressure in your brain. But certain variants in the ADORA2A gene can make you more sensitive to caffeine’s effects - leading to disrupted sleep or insomnia, especially if consumed late in the day. Your genetic profile helps determine how caffeine affects your sleep and circadian rhythm.
Genes: ADORA2A
Stress Tolerance (10 genes)
Your body’s response to stress is driven by hormones like cortisol and adrenaline but how you process stress is also shaped by your genes. Variants in key genes can influence dopamine sensitivity, emotional regulation, and how resilient you are under pressure. Understanding your genetic stress profile helps you manage triggers more effectively and build long-term resilience.
Genes: XKR6, MIR2113, BDNF, COMT, DCAF5, FKBP5, HTR2A, LINCOO461, NOS1, OXTR
Warrior or Strategist (1 gene)
The COMT gene influences how quickly your brain clears dopamine during stress, shaping how well you perform under pressure. Fast metabolisers tend to stay calm in high-threat situations, while slow metabolisers may excel in complex, detail-heavy tasks. Your COMT type can help explain your natural stress tolerance and the environments where you thrive best.
Genes: COMT
Skin
Skin Ageing (4 genes)
Skin ageing is driven by both genetics and environment - with UV exposure accounting for up to 90% of external ageing. Genes involved in collagen, elastin, and skin remodelling influence how well your skin maintains its structure over time. Small genetic variations can accelerate sagging, wrinkles, and loss of elasticity. Knowing your skin-ageing profile helps guide preventative care from the inside out.
Oxidative Stress (3 genes)
UV exposure triggers free radical production in the skin, accelerating ageing and cellular damage. Your body relies on antioxidant enzymes to neutralise these effects but genetic variations in genes like SOD2, CAT, and GPX1 can reduce their efficiency. If your defences are genetically weaker, you may be more susceptible to oxidative stress from sun and pollution.
Sensitivity to Refined Carbohydrate & Glycation (9 genes)
Advanced glycation end products (AGEs) build up when excess sugar reacts with proteins in the body, accelerating ageing and increasing the risk of chronic disease. Your genetic sensitivity to refined carbs - shaped by genes like ACE, PPARG, PLIN, and TCF7L2 - influences how much glucose lingers in your system to drive this damage. Knowing your glycation risk helps you personalise your carb intake to slow cellular ageing.
Genes: ACE, PPARG, TCF7L2, ADRB2, FTO, CLOCK, PLIN, INSIG, FABP2
Pigmentation (2 genes)
Melanin determines your skin, hair, and eye colour - and your natural protection against UV damage. Genetic variants in genes like MC1R and SLC24A5 influence how much melanin you produce and how it’s distributed. Lighter skin tones may be more vulnerable to sun damage but can produce vitamin D more efficiently. Understanding your melanin profile helps balance sun protection with vitamin D needs.
Genes: MC1R, SLC24A5
Nickel Sensitivity (3 genes)
Nickel is a common trigger for contact allergies, often found in jewellery and everyday items. Variants in genes like GSTM1 and GSTT1 can reduce your body’s ability to detoxify allergens, while TNF influences how strongly you react to irritants. Your genetic profile may explain heightened sensitivity and guide ways to reduce exposure and inflammation.
Detoxification (3 genes)
Your body detoxifies harmful substances by converting them into water-soluble forms for safe elimination. Variants in detox genes like EPHX1, GSTM1, and GSTT1 can reduce this efficiency, increasing your vulnerability to oxidative stress and toxin build-up. Knowing your genetic detox profile helps you target support through diet, lifestyle, and supplementation.
Skin Inflammation (2 genes)
Inflammation is your body’s frontline defence against injury, infection, and cell damage but when poorly regulated, it can become chronic and harmful. Variants in genes like IL6 and TNF can heighten inflammatory responses, increasing your risk for accelerated ageing and long-term health issues. Understanding your inflammation profile allows for targeted nutritional and lifestyle strategies to restore balance.
5 pillars of lifelong performance
Your DNA reports focus on 5 core health systems. Strengthen each, and you build lasting energy, focus, and resilience.
Sleep & Stress
+
Decode your genetic sleep rhythms, and build stress resilience.
Skin
+
Learn how to care for your largest organ and first line of defence.
Methylation
+
Optimise the master switch for energy and detox.
Nutrition
+
Pinpoint the exact nutrients your body actually needs.
Fitness
+
Train smarter by matching intensity to your genes.
US VS THEM
Why smart optimisers choose Stride
Get faster results, deeper insights, and real guidance, not just data. Here’s how Stride stacks up.
| Stride Optimal DNA & Methylation Test | 10x Health System | Ultimate Human | |
|---|---|---|---|
| Genes analysed | 110 | 5 | 13 |
| Results time | 10 days | 4 weeks | 5 weeks |
| 1:1 Expert consultation | |
|
|
| Personalised plan | |
|
|
| Money-back guarantee | |
|
|
| Price | €307 | £499 | $599 |
| Buy Now |
Included with this test
Your results become a ranked plan — not a PDF you'll never open.
Stride Protocols reads your results and lifestyle, connects the findings that relate, and turns them into specific actions ordered by what matters most for your goal. Every line traces back to the exact finding behind it.
AI-generated lifestyle guidance — not medical advice. Paired with a 1:1 consultation with a qualified practitioner. Your data is used only to generate your protocol — never sold, shared, or used to train external models.
Join our community of biotrackers taking control of their health
Real reviews from Stride users.
Why test DNA methylation with Stride?
Deeper Analysis
Most methylation tests on the market look at only a handful of genetic variants. StrideDNA analyse more than 9,000 genetic locations with every sample for the most precision picture of your health.
Data Security
We use strong technical and organisational measures to keep your data safe. It is stored securely and encrypted, and only accessible by the minimum necessary members of our team.
Expert Support
Forget hard to understand lab reports on a static PDF, with no support. StrideDNA results are delivered in your own interactive, world-class portal and every test includes 1:1 support from our expert team of human health practitioners.
Faster turnaround
We work with accredited specialist labs that maintain the highest levels of quality control and turnaround time, ensuring the most accurate results in the shortest possible time.
For the curious.
What is the Optimal DNA & Methylation Test?
The Optimal DNA & Methylation Test is Stride's most comprehensive genetic health analysis. It combines methylation genetics with nutrigenetics, fitness performance, sleep and stress traits, and skin health insights to provide a detailed view of how your body is biologically wired.
Rather than focusing on a single pathway, this test looks across multiple systems to help inform personalised nutrition, supplementation, training, recovery, sleep, and long-term health optimisation.
Was ist der Optimal DNA- & Methylierungstest?
Der Optimal DNA- & Methylierungstest ist Strides umfassendste genetische Gesundheitsanalyse. Er kombiniert Methylierungsgenetik mit Nutrigenetik, Fitnessleistung, Schlaf- und Stressmerkmalen sowie Erkenntnissen zur Hautgesundheit, um einen detaillierten Überblick darüber zu geben, wie Ihr Körper biologisch verschaltet ist.
Anstatt sich auf einen einzelnen Stoffwechselweg zu konzentrieren, betrachtet dieser Test mehrere Systeme, um eine personalisierte Ernährung, Nahrungsergänzung, Training, Regeneration, Schlaf und langfristige Gesundheitsoptimierung zu unterstützen.
¿Qué es el Optimal DNA & Methylation Test?
El Optimal DNA & Methylation Test es el análisis genético de salud más completo de Stride. Combina la genética de la metilación con la nutrigenética, el rendimiento físico, los rasgos de sueño y estrés, y datos sobre la salud de la piel para ofrecerte una visión detallada de cómo está configurado biológicamente tu cuerpo.
En lugar de centrarse en una única ruta, este test analiza múltiples sistemas para ayudar a orientar la nutrición personalizada, la suplementación, el entrenamiento, la recuperación, el sueño y la optimización de la salud a largo plazo.
¿Por qué es importante la metilación para la salud y cómo afectan a esta las variantes genéticas?
La metilación es un proceso bioquímico fundamental que favorece la expresión génica, la detoxificación, la producción de energía, la función inmunitaria, el equilibrio de los neurotransmisores, el metabolismo hormonal y la regulación de los lípidos.
Las variantes genéticas en genes relacionados con la metilación, como MTHFR, MTR, MTRR, COMT, BHMT y CBS, pueden influir en la eficiencia con la que tu cuerpo convierte y utiliza nutrientes como el folato y la vitamina B12.
Conocer tus variantes genéticas permite adaptar con mayor precisión las estrategias de nutrición, suplementación y estilo de vida para favorecer una metilación óptima.
Warum ist Methylierung für die Gesundheit wichtig und wie beeinflussen genetische Varianten sie?
Methylierung ist ein zentraler biochemischer Prozess, der die Genexpression, Entgiftung, Energieproduktion, Immunfunktion, den Neurotransmitter-Haushalt, den Hormonstoffwechsel und die Lipidregulation unterstützt.
Genetische Varianten in methylierungsbezogenen Genen wie MTHFR, MTR, MTRR, COMT, BHMT und CBS können beeinflussen, wie effizient Ihr Körper Nährstoffe wie Folat und Vitamin B12 umwandelt und nutzt.
Das Verständnis Ihrer genetischen Varianten ermöglicht es, Ernährungs-, Nahrungsergänzungs- und Lebensstilstrategien präziser auf die Unterstützung einer optimalen Methylierung abzustimmen.
Why is methylation important for health, and how do genetic variants affect it?
Methylation is a core biochemical process that supports gene expression, detoxification, energy production, immune function, neurotransmitter balance, hormone metabolism, and lipid regulation.
Genetic variants in methylation-related genes such as MTHFR, MTR, MTRR, COMT, BHMT, and CBS can influence how efficiently your body converts and uses nutrients like folate and vitamin B12.
Understanding your genetic variants allows nutrition, supplementation, and lifestyle strategies to be tailored more precisely to support optimal methylation.
What is included with the Optimal DNA & Methylation Test?
Your package includes:
- At-home DNA test kit with prepaid UK lab return
- Five detailed methylation pathway reports
- Twenty-four nutrigenetic reports
- Four genetic fitness reports covering power and endurance, aerobic response, recovery efficiency, and injury predisposition
- Five genetic mental cognition reports covering chronotype, sleep quality, caffeine response, stress tolerance, and cognitive style
- Seven genetic skin reports covering skin ageing, oxidative stress, glycation sensitivity, pigmentation, nickel sensitivity, detoxification, and inflammation
- One-to-one support from qualified health professionals, including dieticians
- Access to the Stride digital health platform
Was ist im Optimal DNA- & Methylierungstest enthalten?
Ihr Paket umfasst:
- DNA-Testkit für zu Hause mit vorfrankierter Rücksendung ans UK-Labor
- Fünf detaillierte Berichte zu Methylierungswegen
- Vierundzwanzig nutrigenetische Berichte
- Vier genetische Fitnessberichte zu Kraft und Ausdauer, aerober Reaktion, Regenerationseffizienz und Verletzungsanfälligkeit
- Fünf genetische Berichte zur mentalen Kognition zu Chronotyp, Schlafqualität, Koffeinreaktion, Stresstoleranz und kognitivem Stil
- Sieben genetische Hautberichte zu Hautalterung, oxidativem Stress, Glykationsempfindlichkeit, Pigmentierung, Nickel-Empfindlichkeit, Entgiftung und Entzündung
- Persönliche Beratung durch qualifizierte Gesundheitsfachkräfte, einschließlich Diätolog:innen
- Zugang zur digitalen Gesundheitsplattform von Stride
¿Qué incluye el Optimal DNA & Methylation Test?
Tu paquete incluye:
- Kit de test de ADN para hacer en casa con devolución prepagada al laboratorio del Reino Unido
- Cinco informes detallados de las rutas de metilación
- Veinticuatro informes nutrigenéticos
- Cuatro informes genéticos de forma física que abarcan potencia y resistencia, respuesta aeróbica, eficiencia de recuperación y predisposición a lesiones
- Cinco informes genéticos de cognición mental que abarcan el cronotipo, la calidad del sueño, la respuesta a la cafeína, la tolerancia al estrés y el estilo cognitivo
- Siete informes genéticos de la piel que abarcan el envejecimiento cutáneo, el estrés oxidativo, la sensibilidad a la glicación, la pigmentación, la sensibilidad al níquel, la detoxificación y la inflamación
- Apoyo individual de profesionales de la salud cualificados, incluidos dietistas
- Acceso a la plataforma digital de salud de Stride
¿Qué rutas de metilación analiza el test?
El test Optimal analiza toda la base de la metilación, que incluye:
- Ciclo del folato
- Ciclo de la metionina
- Ruta de la transulfuración
- Ciclo del BH4
- Ciclo de la urea
En conjunto, estas rutas influyen en el procesamiento de nutrientes, el equilibrio de los neurotransmisores, la capacidad de detoxificación, la producción de antioxidantes y la función cardiovascular.
Welche Methylierungswege analysiert der Test?
Der Optimal-Test analysiert die gesamte Methylierungsgrundlage, darunter:
- Folat-Zyklus
- Methionin-Zyklus
- Transsulfurierungs-Stoffwechselweg
- BH4-Zyklus
- Harnstoffzyklus
Zusammen beeinflussen diese Stoffwechselwege die Nährstoffverarbeitung, den Neurotransmitter-Haushalt, die Entgiftungskapazität, die Antioxidantienproduktion und die Herz-Kreislauf-Funktion.
What methylation pathways does the test analyse?
The Optimal test analyses the full methylation foundation, including:
- Folate Cycle
- Methionine Cycle
- Transsulphuration Pathway
- BH4 Cycle
- Urea Cycle
Together, these pathways influence nutrient processing, neurotransmitter balance, detoxification capacity, antioxidant production, and cardiovascular function.
What methylation genes are included?
The test includes a comprehensive methylation gene panel used across Stride's Core and Advanced offerings, embedded within a wider analysis of over 9,000 genetic loci.
Key methylation-related genes include MTHFR (C677T and A1298C), MTR, MTRR, COMT, BHMT, CBS, MAOA, MAOB, DHFR, FUT2, NOS3, PEMT, SOD2, TCN2, and VDR.
This broader context allows methylation results to be interpreted alongside related nutrient and metabolic pathways.
Welche Methylierungsgene sind enthalten?
Der Test umfasst ein umfassendes Methylierungs-Genpanel, das in Strides Core- und Advanced-Angeboten verwendet wird und in eine breitere Analyse von über 9.000 genetischen Loci eingebettet ist.
Zu den wichtigsten methylierungsbezogenen Genen gehören MTHFR (C677T und A1298C), MTR, MTRR, COMT, BHMT, CBS, MAOA, MAOB, DHFR, FUT2, NOS3, PEMT, SOD2, TCN2 und VDR.
Dieser breitere Kontext ermöglicht es, Methylierungsergebnisse zusammen mit verwandten Nährstoff- und Stoffwechselwegen zu interpretieren.
¿Qué genes de metilación se incluyen?
El test incluye un panel completo de genes de metilación que se utiliza en las gamas Core y Advanced de Stride, integrado en un análisis más amplio de más de 9000 loci genéticos.
Entre los genes clave relacionados con la metilación se incluyen MTHFR (C677T y A1298C), MTR, MTRR, COMT, BHMT, CBS, MAOA, MAOB, DHFR, FUT2, NOS3, PEMT, SOD2, TCN2 y VDR.
Este contexto más amplio permite interpretar los resultados de la metilación junto con las rutas de nutrientes y metabólicas relacionadas.
¿Por qué el gen AHCY no se incluye en el informe de metilación de Stride?
Stride se centra en las variantes genéticas que son a la vez clínicamente relevantes y sobre las que se puede actuar.
Las variantes comunes de AHCY son benignas o extremadamente raras, mientras que las mutaciones patógenas se asocian a enfermedades médicas graves y no son apropiadas para los informes habituales destinados al consumidor.
Excluir estas variantes garantiza que los informes sigan siendo significativos, responsables y centrados en la optimización práctica de la salud.
Warum ist das AHCY-Gen nicht in Strides Methylierungsbericht enthalten?
Stride konzentriert sich auf genetische Varianten, die sowohl klinisch relevant als auch umsetzbar sind.
Häufige AHCY-Varianten sind entweder harmlos oder äußerst selten, während pathogene Mutationen mit schweren Erkrankungen verbunden und für eine routinemäßige Verbraucherberichterstattung nicht geeignet sind.
Der Ausschluss dieser Varianten stellt sicher, dass die Berichte aussagekräftig, verantwortungsvoll und auf die praktische Gesundheitsoptimierung ausgerichtet bleiben.
Why is the AHCY gene not included in Stride's Methylation Report?
Stride focuses on genetic variants that are both clinically relevant and actionable.
Common AHCY variants are either benign or extremely rare, while pathogenic mutations are associated with serious medical conditions and are not appropriate for routine consumer reporting.
Excluding these variants ensures reports remain meaningful, responsible, and focused on practical health optimisation.
How does the Optimal test differ from the Core test?
The Optimal test includes everything in the Core test and adds genetic insights related to nutrition, fitness performance, recovery, sleep and stress traits, and skin ageing and inflammation.
It is designed for individuals looking for a more complete, longevity-focused view of their health blueprint.
Wie unterscheidet sich der Optimal-Test vom Core-Test?
Der Optimal-Test umfasst alles aus dem Core-Test und ergänzt genetische Erkenntnisse zu Ernährung, Fitnessleistung, Regeneration, Schlaf- und Stressmerkmalen sowie Hautalterung und Entzündung.
Er ist für Menschen konzipiert, die einen vollständigeren, auf Langlebigkeit ausgerichteten Blick auf ihren Gesundheits-Bauplan suchen.
¿En qué se diferencia el test Optimal del test Core?
El test Optimal incluye todo lo del test Core y añade información genética relacionada con la nutrición, el rendimiento físico, la recuperación, los rasgos de sueño y estrés, y el envejecimiento cutáneo y la inflamación.
Está diseñado para personas que buscan una visión más completa y centrada en la longevidad del plano de su salud.
¿Cómo puede beneficiar este test a mi salud?
El test ofrece orientación personalizada sobre nutrición y suplementación, junto con información para optimizar el entrenamiento, la recuperación, la calidad del sueño, la resiliencia al estrés y la salud de la piel.
Al entender cómo está configurado genéticamente tu cuerpo, puedes tomar decisiones más informadas en lugar de depender de consejos genéricos.
Wie kann dieser Test meiner Gesundheit nutzen?
Der Test liefert personalisierte Empfehlungen für Ernährung und Nahrungsergänzung sowie Erkenntnisse zur Optimierung von Training, Regeneration, Schlafqualität, Stressresistenz und Hautgesundheit.
Wenn Sie verstehen, wie Ihr Körper genetisch verschaltet ist, können Sie fundiertere Entscheidungen treffen, anstatt sich auf allgemeine Ratschläge zu verlassen.
How can this test benefit my health?
The test provides personalised guidance for nutrition and supplementation, alongside insights to optimise training, recovery, sleep quality, stress resilience, and skin health.
By understanding how your body is genetically wired, you can make more informed decisions rather than relying on generic advice.
What kind of support do I receive with my StrideDNA Test?
All plans include one-to-one consultations with qualified dieticians and health practitioners.
Your practitioner helps interpret your results and translate them into a clear, actionable plan tailored to your goals.
Welche Unterstützung erhalte ich mit meinem StrideDNA-Test?
Alle Pakete beinhalten persönliche Beratungen mit qualifizierten Diätolog:innen und Gesundheitsfachkräften.
Ihre Fachkraft hilft Ihnen, Ihre Ergebnisse zu interpretieren und in einen klaren, umsetzbaren und auf Ihre Ziele zugeschnittenen Plan zu übersetzen.
¿Qué tipo de apoyo recibo con mi StrideDNA Test?
Todos los planes incluyen consultas individuales con dietistas y profesionales de la salud cualificados.
Tu profesional te ayuda a interpretar tus resultados y a convertirlos en un plan claro y práctico adaptado a tus objetivos.
¿Cuánto se tarda en recibir mis resultados?
Los resultados suelen entregarse en un plazo de diez días hábiles después de que tu muestra llegue al laboratorio de Stride en el Reino Unido.
Wie lange dauert es, bis ich meine Ergebnisse erhalte?
Die Ergebnisse werden in der Regel innerhalb von zehn Werktagen geliefert, nachdem Ihre Probe im UK-Labor von Stride eingegangen ist.
How long does it take to receive my results?
Results are typically delivered within ten business days after your sample reaches Stride's UK laboratory.
Where is the methylation test available?
Stride ships test kits globally from the UK, including to Europe, North America, Asia-Pacific, Oceania, South America, and Africa.
Delivery times and customs charges vary by location.
If your country is not listed at checkout, please contact hey@getstride.com for guidance.
Wo ist der Methylierungstest verfügbar?
Stride versendet Testkits weltweit aus dem Vereinigten Königreich, unter anderem nach Europa, Nordamerika, Asien-Pazifik, Ozeanien, Südamerika und Afrika.
Lieferzeiten und Zollgebühren variieren je nach Standort.
Wenn Ihr Land beim Checkout nicht aufgeführt ist, wenden Sie sich bitte an hey@getstride.com.
¿Dónde está disponible el test de metilación?
Stride envía kits de test a todo el mundo desde el Reino Unido, incluyendo Europa, Norteamérica, Asia-Pacífico, Oceanía, Sudamérica y África.
Los plazos de entrega y los gastos de aduana varían según la ubicación.
Si tu país no aparece en el proceso de compra, ponte en contacto con hey@getstride.com para obtener ayuda.
¿Puedo hacerme este test si soy menor de 18 años?
Los tests de StrideDNA están diseñados para adultos de 18 años en adelante.
La realización de pruebas a menores de 18 años solo debe gestionarla un padre, una madre o un tutor legal, e idealmente debe interpretarse con un profesional sanitario cualificado. Las regulaciones y la disponibilidad para menores varían según el país.
Kann ich diesen Test machen, wenn ich unter 18 bin?
StrideDNA-Tests sind für Erwachsene ab 18 Jahren konzipiert.
Tests für Personen unter 18 Jahren sollten nur von einem Elternteil oder einer erziehungsberechtigten Person veranlasst und idealerweise mit einer qualifizierten medizinischen Fachkraft interpretiert werden. Vorschriften und Verfügbarkeit für Minderjährige variieren je nach Land.
Can I take this test if I am under 18?
StrideDNA tests are designed for adults aged 18 and over.
Testing for individuals under 18 should only be arranged by a parent or legal guardian and ideally interpreted with a qualified healthcare professional. Regulations and availability for minors vary by country.
Can this test tell me my epigenetic or biological age?
No. This is a genetic methylation test, not an epigenetic age test.
It analyses inherited DNA variants that influence how your methylation pathways function across your lifetime. Epigenetic age testing instead measures methylation marks on DNA that change over time in response to lifestyle, stress, illness, and ageing.
Both approaches are valid, but they answer different questions.
Our top-tier product, StrideOne, includes a separate biological age feature based on nine blood biomarkers. This uses the PhenoAge model to estimate biological age from physiological markers rather than DNA methylation.
Kann mir dieser Test mein epigenetisches oder biologisches Alter verraten?
Nein. Dies ist ein genetischer Methylierungstest, kein epigenetischer Alterstest.
Er analysiert vererbte DNA-Varianten, die beeinflussen, wie Ihre Methylierungswege im Laufe Ihres Lebens funktionieren. Epigenetische Alterstests messen hingegen Methylierungsmarker an der DNA, die sich im Laufe der Zeit als Reaktion auf Lebensstil, Stress, Krankheit und Alterung verändern.
Beide Ansätze sind valide, beantworten aber unterschiedliche Fragen.
Unser Spitzenprodukt StrideOne enthält eine separate Funktion zum biologischen Alter, die auf neun Blut-Biomarkern basiert. Sie nutzt das PhenoAge-Modell, um das biologische Alter aus physiologischen Markern statt aus der DNA-Methylierung zu schätzen.
¿Puede este test decirme mi edad epigenética o biológica?
No. Este es un test genético de metilación, no un test de edad epigenética.
Analiza variantes heredadas del ADN que influyen en cómo funcionan tus rutas de metilación a lo largo de tu vida. En cambio, los tests de edad epigenética miden las marcas de metilación en el ADN que cambian con el tiempo en respuesta al estilo de vida, el estrés, las enfermedades y el envejecimiento.
Ambos enfoques son válidos, pero responden a preguntas diferentes.
Nuestro producto de gama más alta, StrideOne, incluye una función independiente de edad biológica basada en nueve biomarcadores sanguíneos. Esta utiliza el modelo PhenoAge para estimar la edad biológica a partir de marcadores fisiológicos en lugar de la metilación del ADN.
¿Cómo se compara este test con otros tests de ADN de metilación del mercado?
Muchos tests de ADN de metilación analizan un número reducido de genes principales.
El Optimal DNA & Methylation Test de Stride incluye un panel más amplio y clínicamente relevante que cubre toda la base de la metilación y las rutas de nutrientes y metabólicas relacionadas.
Esta cobertura más amplia permite obtener información más precisa sobre las necesidades de nutrientes, los cofactores y los efectos posteriores.
Wie schneidet dieser Test im Vergleich zu anderen Methylierungs-DNA-Tests auf dem Markt ab?
Viele Methylierungs-DNA-Tests analysieren nur eine kleine Anzahl zentraler Gene.
Strides Optimal DNA- & Methylierungstest umfasst ein breiteres, klinisch relevantes Panel, das die gesamte Methylierungsgrundlage sowie verwandte Nährstoff- und Stoffwechselwege abdeckt.
Diese größere Abdeckung ermöglicht präzisere Erkenntnisse zu Nährstoffbedarf, Kofaktoren und nachgelagerten Effekten.
How does this test compare to other methylation DNA tests on the market?
Many methylation DNA tests analyse a small number of core genes.
Stride's Optimal DNA & Methylation Test includes a broader, clinically relevant panel that covers the full methylation foundation and related nutrient and metabolic pathways.
This wider coverage allows for more precise insight into nutrient requirements, cofactors, and downstream effects.
Should I combine this DNA test with blood testing?
Genetic testing explains your biological capacity, while blood testing shows your current nutritional and metabolic status.
Combining DNA results with blood markers such as folate, vitamin B12, homocysteine, and key minerals allows supplement choices and dosing to be tailored more accurately.
If you want to explore the relationship between your DNA and blood biomarkers in more depth, consider our StrideOne or Vital Duo options.
Sollte ich diesen DNA-Test mit einem Bluttest kombinieren?
Genetische Tests erklären Ihre biologische Veranlagung, während Bluttests Ihren aktuellen Nährstoff- und Stoffwechselstatus zeigen.
Die Kombination von DNA-Ergebnissen mit Blutmarkern wie Folat, Vitamin B12, Homocystein und wichtigen Mineralstoffen ermöglicht es, die Auswahl und Dosierung von Nahrungsergänzungsmitteln genauer abzustimmen.
Wenn Sie den Zusammenhang zwischen Ihrer DNA und Ihren Blut-Biomarkern näher erkunden möchten, sollten Sie unsere StrideOne- oder Vital-Duo-Optionen in Betracht ziehen.
¿Debería combinar este test de ADN con análisis de sangre?
Las pruebas genéticas explican tu capacidad biológica, mientras que los análisis de sangre muestran tu estado nutricional y metabólico actual.
Combinar los resultados del ADN con marcadores sanguíneos como el folato, la vitamina B12, la homocisteína y minerales clave permite adaptar con mayor precisión la elección y la dosis de los suplementos.
Si quieres explorar con más profundidad la relación entre tu ADN y tus biomarcadores sanguíneos, considera nuestras opciones StrideOne o Vital Duo.
Find out what your body is actually trying to tell you.
Answer 8 quick questions and get a free personalised report - covering which area of your biology is most worth looking at first, what testing in that area reveals, and what actions become available once you have that data.
Where do you feel you're operating below your potential right now?
Methylation & Cellular Health
Your biology is signalling a methylation upgrade - here’s what that means and what to do about it.