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Stride Health Group

Stride Health Group Ltd
Company No 05158025
Lamas Road
Badersfield
Norwich
England
NR10 5FB
UK

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Don’t just test.
Transform.

Every Stride bundle pairs the right test with the right support, so insight turns into action, and saves you up to 35%.

Trustpilot
Save $185 Gut Stack

Gut Stack

Optimal Biome test, then 3 months of GS-01 pre & probiotics to act on what you find.

$529 $344

Shop Gut Stack
Save $325 Optimal Duo

Optimal Duo

Advanced DNA and microbiome testing, paired with targeted daily supplementation.

$929 $604

Shop Optimal Duo
Save $199 Methylation Stack

Methylation Stack

Advanced DNA and methylation testing, paired with MS-01 methylation support.

$569 $370

Shop Methylation Stack

See all bundles →

Stride offers clinically grounded DNA methylation testing, designed to provide clear, actionable insight without hype or exaggeration.

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Not sure where to start?

Find out what your body is actually trying to tell you.

Answer 8 quick questions and get a free personalised report - covering which area of your biology is most worth looking at first, what testing in that area reveals, and what actions become available once you have that data.

Take the assessment
Question 1 of 8

Where do you feel you're operating below your potential right now?

My energy I run out of steam, crash after lunch, or rely on caffeine more than I'd like
My focus and mental clarity Brain fog, difficulty concentrating, or feeling mentally slower than I should
My mood and stress resilience Anxiety, emotional ups and downs, or difficulty properly switching off
Your result

Methylation & Cellular Health

Your biology is signalling a methylation upgrade - here’s what that means and what to do about it.

The Science

What is DNA methylation?

DNA methylation is a core biological process that helps regulate how your body processes key nutrients linked to energy, mood, and detoxification.


Your methylation capacity is largely genetic. Most notably, methylation is influenced by the MTHFR gene and reflects inherited biochemical function, not epigenetic ageing. This test is not diagnostic and does not predict disease; it’s an educational tool to support informed nutrition and lifestyle choices.

Why people test
Order your kit

Nutrient processing and utilisation

Find out how efficiently your body converts and uses key nutrients like folate, B12, B6 and choline. Stride’s methylation test reveals where nutrient bottlenecks may be limiting energy, detoxification and brain function.

Provide your DNA sample

Cellular maintenance

Your methylation cycles help drive DNA repair, antioxidant production and everyday cellular maintenance. DNA testing shows where these pathways could be under extra strain, before sub-optimal functioning shows up as fatigue or poor recovery.

In-house lab testing

Stress response

Methylation pathways are central to neurotransmitter balance, adrenaline clearance and nitric oxide production. This test helps explain why stress hits you harder, and how to support calmer, more resilient stress biochemistry.

Get your personalised report

Long-term health optimisation

Efficient methylation underpins detoxification, inflammation control and healthy ageing. By understanding your methylation cycles, you can proactively support long-term health rather than reacting once problems appear.

DNA Methylation

What the test analyses
Saliva-based DNA test

This test uses a simple saliva sample collected at home and returned by post. Your DNA is stable over time, so you only need to test once to understand your inherited methylation capacity.

Analyses genes in methylation

The analysis examines key genetic control points within the methylation system, including the MTHFR gene. These variations can influence how effectively your body handles folate, B vitamins, and other methyl-dependent nutrients.

Structured, readable interpretation

Results are presented in a clear, structured format designed to be easy to understand. The report translates complex genetic data into practical, educational insights without medical diagnosis or disease prediction.

What the test analyses

Our Tests

The Stride DNA & Methylation Test

Our DNA & Methylation Test comes in three levels, so you can choose the depth of genetic insight that suits you. Every level uses the same sample and interpretation standards.

Save DNA & Methylation Test

Health Tests

DNA & Methylation Test

Genetic methylation testing, three levels

From $229  $172

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What gut microbiome testing shows

Microbiome tests

What gut microbiome testing shows
What gut microbiome testing shows

Gut microbiome testing analyses the balance and diversity of bacteria in your gut, often referred to as gut health. These microbes influence digestion, nutrient absorption, inflammation, and gut–brain communication.

How it complements genetics

Genetic testing shows your inherited blueprint, while microbiome testing reflects how your gut responds to diet, lifestyle, and environment. Used together, DNA and gut microbiome testing provide a broader view of gut health and nutrient processing.

That it is optional, not a replacement

Gut microbiome testing is an optional add-on for people seeking deeper insight into gut health. It complements DNA testing but does not replace it, as each test measures different biological systems.

Bundles

For those seeking a broader view, DNA methylation testing can be combined with gut microbiome analysis.

View Bundles
Bundles

Stride

From results to action: Guidance & coaching
Deeper Analysis

Personalised nutrition guidance

Your results are translated into personalised nutrition guidance tailored to your genetics and gut microbiome. This helps you make clearer, more confident food and supplement choices.

Faster turnaround

Optional 1:1 coaching

Optional 1:1 coaching is available if you want personalised support beyond your report. Sessions focus on turning insights into practical, sustainable changes.

Expert Support

Delivered by qualified dieticians

All guidance and coaching are delivered by qualified dietitians and nutrition experts. This ensures recommendations are evidence-based, responsible, and aligned with best practice.

US VS THEM

Why smart optimisers choose Stride

Get faster results, deeper insights, and real guidance, not just data. Here’s how Stride stacks up.

Stride Optimal DNA & Methylation Test 10x Health System Ultimate Human
Genes analysed 110 5 13
Results time 10 days 4 weeks 5 weeks
1:1 Expert consultation Yes No No
Personalised plan Yes No No
Money-back guarantee Yes No No
Price $359 $599 $679

As featured in

Financial Times Forbes The Telegraph Fitt Insider Sheerluxe The Standard Red Country & Town House Luxurious Magazine InTouch Rugby

Ambassadors

Trusted by the leading minds in health and performance

From clinical pioneers to Olympic champions, Stride is the preventative health system backed by those who know best.

Dr William Li

“What excites me about Stride is how we can show people what’s happening inside their bodies and then use diet and lifestyle change to transform their future towards optimal health. It’s a platform that turns science into daily practice.”

Dr William Li

Physician, Scientist & BESTSELLING AUTHOR

Dr Rupy Aujla

“Stride is the service that finally connects the dots between testing, lifestyle and real-world behaviour change. Most services give you data; Stride gives you direction. This is the kind of preventative, personalised approach we need more of.”

Dr Rupy Aujla

NHS GP & Founder of The Doctor’s Kitchen

Greg Rutherford

“As Olympic champion, I learned that the smallest details can be the difference between good and great. Now that I’m at a different stage of my life, what I love about Stride is that it brings that same performance mindset to everyday health.”

Greg Rutherford, MBE

Olympic Gold Medallist & Broadcaster

For the curious.

What is the Optimal DNA & Methylation Test?

The Optimal DNA & Methylation Test is Stride's most comprehensive genetic health analysis. It combines methylation genetics with nutrigenetics, fitness performance, sleep and stress traits, and skin health insights to provide a detailed view of how your body is biologically wired.

Rather than focusing on a single pathway, this test looks across multiple systems to help inform personalised nutrition, supplementation, training, recovery, sleep, and long-term health optimisation.

Why is methylation important for health, and how do genetic variants affect it?

Methylation is a core biochemical process that supports gene expression, detoxification, energy production, immune function, neurotransmitter balance, hormone metabolism, and lipid regulation.

Genetic variants in methylation-related genes such as MTHFR, MTR, MTRR, COMT, BHMT, and CBS can influence how efficiently your body converts and uses nutrients like folate and vitamin B12.

Understanding your genetic variants allows nutrition, supplementation, and lifestyle strategies to be tailored more precisely to support optimal methylation.

What is included with the Optimal DNA & Methylation Test?

Your package includes:

  • At-home DNA test kit with prepaid UK lab return
  • Five detailed methylation pathway reports
  • Twenty-four nutrigenetic reports
  • Four genetic fitness reports covering power and endurance, aerobic response, recovery efficiency, and injury predisposition
  • Five genetic mental cognition reports covering chronotype, sleep quality, caffeine response, stress tolerance, and cognitive style
  • Seven genetic skin reports covering skin ageing, oxidative stress, glycation sensitivity, pigmentation, nickel sensitivity, detoxification, and inflammation
  • One-to-one support from qualified health professionals, including dieticians
  • Access to the Stride digital health platform

What methylation pathways does the test analyse?

The Optimal test analyses the full methylation foundation, including:

  • Folate Cycle
  • Methionine Cycle
  • Transsulphuration Pathway
  • BH4 Cycle
  • Urea Cycle

Together, these pathways influence nutrient processing, neurotransmitter balance, detoxification capacity, antioxidant production, and cardiovascular function.

What methylation genes are included?

The test includes a comprehensive methylation gene panel used across Stride's Core and Advanced offerings, embedded within a wider analysis of over 9,000 genetic loci.

Key methylation-related genes include MTHFR (C677T and A1298C), MTR, MTRR, COMT, BHMT, CBS, MAOA, MAOB, DHFR, FUT2, NOS3, PEMT, SOD2, TCN2, and VDR.

This broader context allows methylation results to be interpreted alongside related nutrient and metabolic pathways.

Why is the AHCY gene not included in Stride's Methylation Report?

Stride focuses on genetic variants that are both clinically relevant and actionable.

Common AHCY variants are either benign or extremely rare, while pathogenic mutations are associated with serious medical conditions and are not appropriate for routine consumer reporting.

Excluding these variants ensures reports remain meaningful, responsible, and focused on practical health optimisation.

How does the Optimal test differ from the Core test?

The Optimal test includes everything in the Core test and adds genetic insights related to nutrition, fitness performance, recovery, sleep and stress traits, and skin ageing and inflammation.

It is designed for individuals looking for a more complete, longevity-focused view of their health blueprint.

How can this test benefit my health?

The test provides personalised guidance for nutrition and supplementation, alongside insights to optimise training, recovery, sleep quality, stress resilience, and skin health.

By understanding how your body is genetically wired, you can make more informed decisions rather than relying on generic advice.

What kind of support do I receive with my StrideDNA Test?

All plans include one-to-one consultations with qualified dieticians and health practitioners.

Your practitioner helps interpret your results and translate them into a clear, actionable plan tailored to your goals.

How long does it take to receive my results?

Results are typically delivered within ten business days after your sample reaches Stride's UK laboratory.

Where is the methylation test available?

Stride ships test kits globally from the UK, including to Europe, North America, Asia-Pacific, Oceania, South America, and Africa.

Delivery times and customs charges vary by location.

If your country is not listed at checkout, please contact hey@getstride.com for guidance.

Can I take this test if I am under 18?

StrideDNA tests are designed for adults aged 18 and over.

Testing for individuals under 18 should only be arranged by a parent or legal guardian and ideally interpreted with a qualified healthcare professional. Regulations and availability for minors vary by country.

Can this test tell me my epigenetic or biological age?

No. This is a genetic methylation test, not an epigenetic age test.

It analyses inherited DNA variants that influence how your methylation pathways function across your lifetime. Epigenetic age testing instead measures methylation marks on DNA that change over time in response to lifestyle, stress, illness, and ageing.

Both approaches are valid, but they answer different questions.

Our top-tier product, StrideOne, includes a separate biological age feature based on nine blood biomarkers. This uses the PhenoAge model to estimate biological age from physiological markers rather than DNA methylation.

How does this test compare to other methylation DNA tests on the market?

Many methylation DNA tests analyse a small number of core genes.

Stride's Optimal DNA & Methylation Test includes a broader, clinically relevant panel that covers the full methylation foundation and related nutrient and metabolic pathways.

This wider coverage allows for more precise insight into nutrient requirements, cofactors, and downstream effects.

Should I combine this DNA test with blood testing?

Genetic testing explains your biological capacity, while blood testing shows your current nutritional and metabolic status.

Combining DNA results with blood markers such as folate, vitamin B12, homocysteine, and key minerals allows supplement choices and dosing to be tailored more accurately.

If you want to explore the relationship between your DNA and blood biomarkers in more depth, consider our StrideOne or Vital Duo options.