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hey@getstride.com
Stride Health Group
Stride Health Group Ltd
Company No 05158025
Lamas Road
Badersfield
Norwich
England
NR10 5FB
UK
Core Methylation Test
Your at-home DNA methylation test for better health
Analyse 5 key methylation pathways and turn insights into action
Excellent Score 4.8 out of 5
- Explore five key methylation cycles (folate, methionine, transsulphuration, BH4, urea)
- See how efficiently you detoxify, repair DNA, and convert nutrients into energy
- Choose diet types and supplements guided by genes such as MTHFR, COMT, and others
Secure, private platform
30-day money-back guarantee
As featured in
Core health. It’s yours to take.
Build your foundation with essential DNA methylation insights
Have you ever wondered why the same health advice doesn’t work for everyone? The answer may lie in your methylation profile — a key biological process that helps control how your genes function. When these pathways aren’t working optimally, your body may struggle to perform at its best.
Methylation is similar to transforming raw materials into usable forms, playing a role in nearly every biochemical reaction within our cells, happening billions times per second.
Methylation is crucial for numerous body processes, including gene expression, energy production, fat metabolism, immune responses, detoxification and neurotransmitter regulation. Factors like DNA, diet, toxin exposure, and stress influence methylation.
Genetic mutations and deficiencies in key dietary cofactors (e.g., the MTHFR gene) can impair methylation and affect the body's ability to convert nutrients effectively. This can cause various chronic conditions, such as impaired immunity, fatigue, cardiovascular disease, neurological disorders, cancers, and mood disorders.
Methylation Profile Reports
The StrideDNA Methylation Report examines the genetic variants that influence your body's methylation profile capabilities.
It highlights the activity of key methylation genes, such as MTHFR, during five crucial cycles, including the Folate Cycle. Understanding these genetic influences can help you optimise nutrient absorption, DNA repair, detoxification, neurotransmitter production, and more.
Armed with this knowledge, you can make informed choices about your lifestyle and wellness efforts to support your methylation pathways and enhance your overall health and longevity.
What's Included (5 reports)
Folate Cycle (5 genes)
The Folate Cycle converts dietary folate into usable forms for critical bodily processes. Understanding your genetic predispositions is crucial because variations like impaired MTHFR or DHFR function can significantly reduce folate processing efficiency.
Genes: DHFR, MTHFD1, MTHFR (A1298C), MTHFR (C677T)
Methionine Cycle (6 genes)
The Methionine Cycle drives methylation by producing SAMe - vital for gene expression, detox, and brain chemistry. Variants here can raise homocysteine and stall key pathways like BH4 and Transsulphuration. A methylation panel can uncover blocks behind fatigue, poor focus, and hormonal imbalance.
Genes: MTR, MTRR, FUT2, TCN2, PEMT, BHMT
The Transsulphuration Pathway (2 genes)
This pathway clears homocysteine by turning it into cysteine - fuel for glutathione and taurine. Genetic blocks here can impair detox, raise sulphite toxicity, and drive brain fog and burnout. Screening for these variants can reveal why your stress and recovery systems are under strain.
Genes: CBS (C699T), GSS
The BH4 Cycle (4 genes)
The BH4 Cycle makes key neurotransmitters like dopamine and serotonin and supports nitric oxide and thyroid function. It depends on folate and SAMe from other cycles. Variants can lead to mood issues, poor sleep, and low motivation. Knowing your BH4 profile helps explain and address deeper neurological imbalances.
Genes: MTHFR (A1298C), COMT, VDR, MAOA, MAOB
Urea Cycle (2 genes)
The Urea Cycle detoxifies ammonia by converting it into urea for safe excretion - a vital process linked to liver function, nitrogen balance, and brain health. It also produces arginine, needed for nitric oxide (NO), which supports blood flow and protects your heart. Variants here or low BH4 can impair NO production, increasing oxidative stress and cardiovascular risk.
Genes: NOS3, SOD2
Why Stride?
Deeper Analysis
Most methylation tests only assess a handful of variants. StrideDNA analyses over 9,000 genetic locations for a more precise picture of your methylation pathways.
Data Security
We use strong technical and organisational measures to keep your data safe. It is stored securely and encrypted, and only accessible by the minimum necessary members of our team.
Expert Support
Skip static PDFs. Your results live in an interactive portal, and every test includes a 1:1 session with our expert practitioners to turn data into action.
Faster turnaround
Because we operate our own laboratory, we deliver high-quality results quickly and at lower cost.
Join tens of thousands already taking control of their health.
Real reviews from Stride users.
Reviews
“I’m so happy I found this test! It always felt strange to me that I had to live so clean and healthy just to feel okay. I was also really concerned about why, even when I was eating well and at a healthy weight, I still had terrible cellulite and vein issues. Since I started taking the recommended vitamins, I’ve noticed such a big change—my legs feel so much lighter, and the size of my veins has reduced significantly. I believe it’s because my body is now able to detox and function more efficiently. Even my cellulite has improved so much. Thank you!"
Nancy Marahi Ruiz A.
5
Reviews
“I have suffered from chronic health conditions for years now and have been treated with medication which doesn’t help much and certainly doesn’t cure. This DNA test has changed everything for me. I have learned unfortunately I have terrible genetics, can’t methylate and need lots of extra nutrition in areas I would never have thought of. Once you get over the disappointment of being born with dysfunctional genes you realise that with that specific knowledge, is power to get your health back, what to avoid, what to be aware of (higher risks for certain diseases) and more importantly what you can do to strengthen your body through vitamins, amino acids, oils and minerals. Life changing info that can be both preventative and natural treatment for better health, energy and wellbeing. An amazing company. The vitamins sachets are delicious too!”
Amy W.
5
Reviews
“I have been a user for 6 months now and in my opinion Stride has been a key factor in rebalancing my body chemistry. The benefits that I have seen have ranged from gross benefits such as cessation of bloating and unease in my bowels to subtle improvements in nail & hair growth.”
Parag P.
5
Reviews
“After 17 years on anti-depressants for anxiety due to low serotonin, I have slowly managed to wean off the medication, usually always resulting in a huge relapses of anxiety and going back on them in a hurry. This time I have put measures in place to avoid this happening which was getting a DNA test done and purchasing their recommended daily methylation support stack which to my surprise has worked wonders and has kept me at a good level where I am feeling good, sleeping well, not feeling drowsy in the morning and overall feeling less anxious! You guys are doing a great job! Keep up the good work at Stride!”
David G.
5
Our DNA + Methylation Packages
| Core Methylation Test | Advanced DNA & Methylation | Optimal DNA & Methylation | Gary Brecka's 10X Health Genetic Test | |
|---|---|---|---|---|
| Genes analysed | 19 | 59 | 110 | 5 |
| Methylation Reports | 5 | 5 | 5 | 5 |
| Nutrition Reports | - | 24 | 24 | - |
| Fitness Reports | - | - | 4 | - |
| Sleep & Stress Reports | - | - | 5 | - |
| Skin Reports | - | - | 8 | - |
| Turnaround time | 10 business days from sample receipt | 10 business days from sample receipt | 10 business days from sample receipt | 4 weeks |
| Expert consultations included | Yes | Yes | Yes | No (available for $120 per call) |
| Human support | Dietetics expert or Registered Physiologist | Dietetics expert or Registered Physiologist | Dietetics expert or Registered Physiologist | Unqualified Wellness Expert |
| Online results portal | Yes | Yes | Yes | No |
| Personalised health recommendations | Yes | Yes | Yes | Limited |
| Price | €259 €207.20 | €319 €223.30 | €439 €307.30 | $599 |
| You are Here | Learn More | Learn More |
Full stack precision health
Stride is a holistic personalised health ecosystem. By joining us with a StrideDNA test you’ll unlock access to everything Stride offers, from further diagnostic testing to cutting-edge supplementation.
Phase 1: Assessment
Choose your report insight level and order your Core Methylation test kit.
🧬 StrideDNA At-Home Test
We’ll ship you our easy-to-use home DNA testing kit, for a world of insights with just a simple cheek swab.
Phase 2: Discovery
Return your StrideDNA kit using our prepaid return mailer and we’ll analyse your sample at our advanced in-house laboratory.
💉 Precision laboratory analysis
We’ll extract your DNA and analyse your sample for over 9000 genetic locations, all within ten working days
📊 Genetic reports
You'll get your 5 methylation pathway reports with clear, prioritised actions.
Phase 3: Action
Once you’ve got your StrideDNA results, you’ll unlock a world of personalised health insights with clear support for next steps.
💧 Supplements
With your results, you’ll unlock eligibility for one of our tailored supplements, either StrideDaily or MS-01.
🩺 1:1 Expert Consultation
Our team of holistic functional health practitioners are available for free consultations to help reach your goals.
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Supplements
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MS-01
Daily support stack with active-form vitamin B6, B9 & B12 to support methylation.
Learn MoreFor the curious.
What is the Core Methylation Test?
The Stride Core Methylation Test is an at-home DNA test that analyses key methylation pathways and genetic markers affecting nutrient processing, detoxification, energy, and mood. It provides clear, actionable insights to help you personalise nutrition and supplements.
Why is methylation important for health, and how do genetic variants affect it?
Methylation is a core biochemical process that supports gene expression, detoxification, energy production, immune function, neurotransmitter balance, and lipid metabolism.
Genetic variants in methylation-related genes (e.g., MTHFR, MTR, MTRR, COMT, BHMT, CBS) can influence how efficiently your body converts and uses nutrients such as folate and B12, which may affect energy, mood, cardiovascular and neurological health.
Understanding your variants helps tailor nutrition and supplementation (e.g., folate form and dose, B-vitamin support), alongside lifestyle changes to optimise methylation.
What's included with the Core Methylation Test?
Your kit includes:
- Easy-to-use at-home DNA test kit
- Free return mailer to our UK laboratory
- 5 Methylation Reports: Folate Cycle, Methionine Cycle, Transsulphuration Pathway, BH4 Cycle, Urea Cycle
- 1:1 Health Expert Support (including dietician)
- Access to the Stride digital health platform
What methylation pathways does it analyse?
The Core Methylation Test covers the Folate Cycle, Methionine Cycle, Transsulphuration Pathway, BH4 Cycle, and Urea Cycle to help you understand where methylation efficiency may be supported.
What methylation genes are included?
The report evaluates over 9,000 locations and key SNPs such as MTHFR (C677T, A1298C), MTR, MTRR, COMT, BHMT, CBS, MAOA, MAOB, DHFR, FUT2, NOS3, PEMT, SOD2, TCN2, and VDR.
Why is the AHCY gene not included in Stride's Methylation Report?
We include genes with strong human evidence and clear, modifiable actions.
AHCY SNPs rs41301825 and rs13043752 are regarded as benign and rare; rs121918608 is a very rare pathogenic mutation. Including benign or ultra-rare variants would not add meaningful, actionable insight for most users.
How does the Core Methylation Test differ from other DNA tests?
Stride analyses more genetic locations than most methylation-only tests and delivers results via an interactive platform with expert support, helping you translate data into practical nutrition and supplement strategies.
How can this test benefit my health?
It identifies potential inefficiencies in methylation that can affect energy, detoxification, immune function, neurotransmitters, and nutrient conversion (e.g., folate), guiding targeted diet and supplement choices.
What kind of support do I receive with my StrideDNA Test?
Every Stride test includes 1:1 consultations with qualified dieticians and health practitioners. Our experts interpret your results and help you build a personalised plan.
How long does it take to receive my results?
Your results are typically available within 10 business days after your sample arrives at our UK laboratory.
Where is the methylation test available?
Stride ships globally from our UK-based laboratory across the UK, Europe, North America, Asia-Pacific, Oceania, South America, and Africa. Shipping times and any customs fees vary by location. If your country is not listed, contact hey@getstride.com.
Can I take this test if I’m under 18?
StrideDNA tests are designed for adults (18+).
If you are under 18, testing should only be arranged by a parent or legal guardian, and ideally interpreted with a qualified healthcare professional. Regulatory rules and availability for minors can vary by country.
If you’re unsure, email hey@getstride.com and we’ll advise before you order.